{"_buckets": {"deposit": "7f592f49-64f7-40df-b09c-1fd3da8a493c"}, "_deposit": {"id": "5838", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5838"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00005838"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u524d\u7acb\u817a\u304c\u3093\u7d30\u80de\u5185\u306b\u304a\u3051\u308b\u975e\u6d3b\u6027\u578b\u30a2\u30f3\u30c9\u30ed\u30b2\u30f35\u03b1-androstane-3\u03b2,17\u03b2-diol\u304b\u3089\u306e\u30b8\u30d2\u30c9\u30ed\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5408\u6210\uff1a\u30a2\u30d3\u30e9\u30c6\u30ed\u30f3\u306b\u3088\u308b\u304c\u3093\u7d30\u80de\u51853\u03b2-\u6c34\u9178\u5316\u30b9\u30c6\u30ed\u30a4\u30c9\u8131\u6c34\u7d20\u9175\u7d20\u963b\u5bb3"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-03-23", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2017-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Intratumoural dihydrotestosterone (DHT) synthesis could be an explanation for castration resistance\\nin prostate cancer (PC). By using liquid chromatography-mass spectrometry, we evaluated the\\nintratumoral DHT synthesis from 5\u03b1-androstane-3\u03b2,17\u03b2-diol (3\u03b2-diol), which is inactive androgen metabolized from DHT. 3\u03b2-diol had biochemical potential to be converted to DHT via three metabolic pathways and could stimulate PC cell growth. Especially, 3\u03b2-diol was not only converted back to upstream androgens such as dehydroepiandrosterone (DHEA) or \u03945-androstenediol but also converted directly to DHT which is the main pathway from 3\u03b2-diol to DHT. Abiraterone had a significant influence on the metabolism of DHEA, epiandrosterone and 3\u03b2-diol, by the inhibition of the intratumoural 3\u03b2-hydroxysteroid dehydrogenase (3\u03b2-HSD) activities which is one of key catalysts in androgen metabolic pathway. The direct-conversion of 3\u03b2-diol to DHT was catalysed by 3\u03b2-HSD and abiraterone could inhibit this activity of 3\u03b2-HSD. These results suggest that PC had a mechanism of intratumoural androgen metabolism to return inactive androgen to active androgen and intratumoural DHT synthesis from 3\u03b2-diol is important as one of the mechanisms of castration resistance in PC. Additionally, the inhibition of intratumoural 3\u03b2-HSD activity could be a new approach to castration-resistant prostate\\ncancer treatment.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u5b66\u4f4d\u306e\u7a2e\u985e: \u535a\u58eb\uff08\u533b\u5b66\uff09. \u5831\u544a\u756a\u53f7: \u7532\u7b2c4250\u53f7. \u5b66\u4f4d\u8a18\u756a\u53f7: \u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c728\u53f7. \u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5: \u5e73\u621029\u5e743\u670823\u65e5", "subitem_description_type": "Other"}, {"subitem_description": "Scientific Reports 6 Article number 32198,2016", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": "\u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c728\u53f7", "subitem_description_type": "Other"}]}, 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"attribute_value_mlt": [{"subitem_title": "Dihydrotestosterone synthesis pathways from inactive androgen 5\u03b1-androstane-3\u03b2,17\u03b2-diol in prostate cancer cells: Inhibition of intratumoural 3\u03b2-hydroxysteroid dehydrogenase activities by abiraterone."}, {"subitem_title": "Dihydrotestosterone synthesis pathways from inactive androgen 5\u03b1-androstane-3\u03b2,17\u03b2-diol in prostate cancer cells: Inhibition of intratumoural 3\u03b2-hydroxysteroid dehydrogenase activities by abiraterone.", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "471/561/562"], "permalink_uri": "http://hdl.handle.net/10191/47581", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2018-09-11"}, "publish_date": "2018-09-11", "publish_status": "0", "recid": "5838", "relation": {}, "relation_version_is_last": true, "title": ["Dihydrotestosterone synthesis pathways from inactive androgen 5\u03b1-androstane-3\u03b2,17\u03b2-diol in prostate cancer cells: Inhibition of intratumoural 3\u03b2-hydroxysteroid dehydrogenase activities by abiraterone."], "weko_shared_id": 2}