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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone.

http://hdl.handle.net/10191/47581
db9a179e-849b-42a5-9cb2-3ff86423fc03
名前 / ファイル ライセンス アクション
h28nmk728.pdf 本文 (1.1 MB)
h28nmk728_a.pdf 要旨 (199.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-09-11
タイトル
タイトル Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone.
タイトル
言語 en
タイトル Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone.
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 前立腺がん細胞内における非活性型アンドロゲン5α-androstane-3β,17β-diolからのジヒドロテストステロン合成:アビラテロンによるがん細胞内3β-水酸化ステロイド脱水素酵素阻害
著者 Ando, Takashi

× Ando, Takashi

WEKO 50959

Ando, Takashi

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著者別名
識別子
識別子 50960
識別子Scheme WEKO
姓名
姓名 安藤, 嵩
抄録
内容記述タイプ Abstract
内容記述 Intratumoural dihydrotestosterone (DHT) synthesis could be an explanation for castration resistance\nin prostate cancer (PC). By using liquid chromatography-mass spectrometry, we evaluated the\nintratumoral DHT synthesis from 5α-androstane-3β,17β-diol (3β-diol), which is inactive androgen metabolized from DHT. 3β-diol had biochemical potential to be converted to DHT via three metabolic pathways and could stimulate PC cell growth. Especially, 3β-diol was not only converted back to upstream androgens such as dehydroepiandrosterone (DHEA) or Δ5-androstenediol but also converted directly to DHT which is the main pathway from 3β-diol to DHT. Abiraterone had a significant influence on the metabolism of DHEA, epiandrosterone and 3β-diol, by the inhibition of the intratumoural 3β-hydroxysteroid dehydrogenase (3β-HSD) activities which is one of key catalysts in androgen metabolic pathway. The direct-conversion of 3β-diol to DHT was catalysed by 3β-HSD and abiraterone could inhibit this activity of 3β-HSD. These results suggest that PC had a mechanism of intratumoural androgen metabolism to return inactive androgen to active androgen and intratumoural DHT synthesis from 3β-diol is important as one of the mechanisms of castration resistance in PC. Additionally, the inhibition of intratumoural 3β-HSD activity could be a new approach to castration-resistant prostate\ncancer treatment.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4250号. 学位記番号: 新大院博(医)甲第728号. 学位授与年月日: 平成29年3月23日
内容記述
内容記述タイプ Other
内容記述 Scientific Reports 6 Article number 32198,2016
書誌情報 発行日 2017-03-23
出版者
出版者 新潟大学
DOI
関連識別子
識別子タイプ DOI
関連識別子 info:doi/10.1038/srep32198
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2017-03-23
学位授与番号
学位授与番号 13101甲第4250号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第728号
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