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MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such as cytokines.Little is known about the role of interferon (IFN)-γ in MUC5AC expression in human bronchial epithelial cells. Methods: Human pulmonary mucoepidermoid carcinoma cell line (NCI-H292) and normal human bronchial epithelial (NHBE) cells were used to assess the effects of IFN-γ on MUC5AC transcription. Results: Transforming growth factor (TGF)-α and double-stranded RNA (polyI:C)-induced MUC5AC mRNA and protein expression was repressed by IFN-γin a concentration-dependent manner. IFN-γ showed limited effects on TGF-α and polyI:C-induced activation of epidermal growth factor receptor (EGFR) and extracellular signale-regulated kinase(ERK). 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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ

http://hdl.handle.net/10191/45098
http://hdl.handle.net/10191/45098
a71c5ac4-fa07-4633-9176-5f84576a3d52
名前 / ファイル ライセンス アクション
h28nmk711.pdf 本文 (6.4 MB)
h28nmk711_a.pdf 要旨 (209.2 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2016-12-07
タイトル
タイトル Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ
タイトル
言語 en
タイトル Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ
言語
言語 eng
キーワード
主題Scheme Other
主題 MUC5AC
キーワード
主題Scheme Other
主題 mucin
キーワード
主題Scheme Other
主題 interferon-ɤ
キーワード
主題Scheme Other
主題 bronchial epithelial cells
キーワード
主題Scheme Other
主題 Sp1
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル インターフェロンγによるヒト気道上皮細胞MUC5AC発現抑制
著者 Oyanagi, Takahito

× Oyanagi, Takahito

WEKO 50900

Oyanagi, Takahito

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著者別名
識別子 50901
識別子Scheme WEKO
姓名 小柳, 貴人
抄録
内容記述タイプ Abstract
内容記述 Background: Excessive mucin secretion in the airway is an important feature of airway inflammatory diseases. . MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such MUC5AC expression is regulated by a variety of stimuli such as cytokines.Little is known about the role of interferon (IFN)-γ in MUC5AC expression in human bronchial epithelial cells. Methods: Human pulmonary mucoepidermoid carcinoma cell line (NCI-H292) and normal human bronchial epithelial (NHBE) cells were used to assess the effects of IFN-γ on MUC5AC transcription. Results: Transforming growth factor (TGF)-α and double-stranded RNA (polyI:C)-induced MUC5AC mRNA and protein expression was repressed by IFN-γin a concentration-dependent manner. IFN-γ showed limited effects on TGF-α and polyI:C-induced activation of epidermal growth factor receptor (EGFR) and extracellular signale-regulated kinase(ERK). A chromatin immunoprecipitation assay indicated that Sp1 bound to its cognate sequence located on the MUC5AC promoter. The Sp1inhibitor mithramycin A inhibited MUC5AC mRNA expression, implying a critical role for Sp1 in MUC5AC induction. Importantly, IFN-γ impeded Sp1 binding to the MUC5AC promoter. Conclusions: These results suggest that IFN-γ represses MUC5AC expression, disturbing binding of Sp1 to its target sequences.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4212号. 学位記番号: 新大院博(医)甲第711号. 学位授与年月日: 平成28年9月20日
書誌情報 発行日 2016-09-20
出版者
出版者 新潟大学
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2016-09-20
学位授与番号
学位授与番号 13101甲第4212号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第711号
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