{"_buckets": {"deposit": "226241e2-f2c1-4f69-9cd7-8ae37d600e95"}, "_deposit": {"id": "5799", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5799"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00005799"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u5ddd\u5d0e\u75c5\u9060\u9694\u671f\u306b\u304a\u3051\u308b\u8840\u7ba1\u969c\u5bb3\u306e\u65b0\u305f\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\uff1a\u53ef\u6eb6\u578bLR11"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-09-20", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2016-09-20"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Objective : Coronary artery lesions (CALs)and a risk for early onset of atherosclerosis are major concerns following Kawasaki disease (KD).Intimal smooth muscle cells (SMCs) have an important role in vascular lesions in KD.It is known that soluble LR11 (sLR11) is a novel biomarker for vascular lesions  and LR11 is markedly expressed in intimal  SMCs in  atherosclerotic lesions. In this study, we hypothesized that sLR11 reflects the presence of vascular lesions late after KD. Methods : Twenty-three age-matched controls (group 1) and 59patients with a history of KD were enrolled : 36 with KD had normal coronary arteries or regressed aneurysms (group 2) and 23 had CALs (group 3). Results : Serum sLR11 levels in group 3 (median, interquartile range(IQR):11.1ng/mL,9.3-13.9ng/mL)were significantly higher than those in groups 1(8.4ng/mL,7.1-10.2ng/mL,p\u003c0.001) and 2 (9.0ng/mL,7.7-10.1ng/mL,p\u003c0.001).Levels of sLR11were positively correlated with levels of high sensitivity C-reactive protein (r = 0.480, p \u003c 0.01) and lipoprotein(a) (r = 0.486, p \u003c 0.01). Conclusion : These findings suggest that sLR11 reflects the development of vascular lesions in patients with serious CALs.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u5b66\u4f4d\u306e\u7a2e\u985e: \u535a\u58eb\uff08\u533b\u5b66\uff09. \u5831\u544a\u756a\u53f7: \u7532\u7b2c4211\u53f7. \u5b66\u4f4d\u8a18\u756a\u53f7: \u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c710\u53f7. \u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5: \u5e73\u621028\u5e749\u670820\u65e5", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": "\u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c710\u53f7", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101\u7532\u7b2c4211\u53f7"}]}, "item_6_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "50899", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "\u6e21\u8fba, \u5065\u4e00"}]}]}, "item_6_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u5927\u5b66"}]}, "item_6_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Watanabe, Kenichi"}], "nameIdentifiers": [{"nameIdentifier": "50898", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h28nmk710.pdf", "filesize": [{"value": "240.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 240500.0, "url": {"label": "\u672c\u6587", "url": "https://niigata-u.repo.nii.ac.jp/record/5799/files/h28nmk710.pdf"}, "version_id": "7f4e7f80-28b2-44c3-823e-48cce6af50e7"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h28nmk710_a.pdf", "filesize": [{"value": "197.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 197400.0, "url": {"label": "\u8981\u65e8", "url": "https://niigata-u.repo.nii.ac.jp/record/5799/files/h28nmk710_a.pdf"}, "version_id": "a46618d6-d1a1-48d0-9550-2a0c41c29a39"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "LR11", "subitem_subject_scheme": "Other"}, {"subitem_subject": "smooth muscle cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Kawasaki disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "biomarker", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease"}, {"subitem_title": "Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "471/561/562"], "permalink_uri": "http://hdl.handle.net/10191/45097", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-12-07"}, "publish_date": "2016-12-07", "publish_status": "0", "recid": "5799", "relation": {}, "relation_version_is_last": true, "title": ["Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease"], "weko_shared_id": 2}