{"created":"2021-03-01T06:09:40.276312+00:00","id":5799,"links":{},"metadata":{"_buckets":{"deposit":"226241e2-f2c1-4f69-9cd7-8ae37d600e95"},"_deposit":{"id":"5799","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5799"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00005799","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"川崎病遠隔期における血管障害の新たなバイオマーカー：可溶型LR11"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-20","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-09-20"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective : Coronary artery lesions (CALs)and a risk for early onset of atherosclerosis are major concerns following Kawasaki disease (KD).Intimal smooth muscle cells (SMCs) have an important role in vascular lesions in KD.It is known that soluble LR11 (sLR11) is a novel biomarker for vascular lesions  and LR11 is markedly expressed in intimal  SMCs in  atherosclerotic lesions. In this study, we hypothesized that sLR11 reflects the presence of vascular lesions late after KD. Methods : Twenty-three age-matched controls (group 1) and 59patients with a history of KD were enrolled : 36 with KD had normal coronary arteries or regressed aneurysms (group 2) and 23 had CALs (group 3). Results : Serum sLR11 levels in group 3 (median, interquartile range(IQR):11.1ng/mL,9.3-13.9ng/mL)were significantly higher than those in groups 1(8.4ng/mL,7.1-10.2ng/mL,p<0.001) and 2 (9.0ng/mL,7.7-10.1ng/mL,p<0.001).Levels of sLR11were positively correlated with levels of high sensitivity C-reactive protein (r = 0.480, p < 0.01) and lipoprotein(a) (r = 0.486, p < 0.01). Conclusion : These findings suggest that sLR11 reflects the development of vascular lesions in patients with serious CALs.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 甲第4211号. 学位記番号: 新大院博（医）甲第710号. 学位授与年月日: 平成28年9月20日","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第710号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4211号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"50899","nameIdentifierScheme":"WEKO"}],"names":[{"name":"渡辺, 健一"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"50898","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h28nmk710.pdf","filesize":[{"value":"240.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/5799/files/h28nmk710.pdf"},"version_id":"7f4e7f80-28b2-44c3-823e-48cce6af50e7"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h28nmk710_a.pdf","filesize":[{"value":"197.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/5799/files/h28nmk710_a.pdf"},"version_id":"a46618d6-d1a1-48d0-9550-2a0c41c29a39"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"LR11","subitem_subject_scheme":"Other"},{"subitem_subject":"smooth muscle cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Kawasaki disease","subitem_subject_scheme":"Other"},{"subitem_subject":"biomarker","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease"},{"subitem_title":"Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-12-07"},"publish_date":"2016-12-07","publish_status":"0","recid":"5799","relation_version_is_last":true,"title":["Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:39:01.022392+00:00"}