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Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer
http://hdl.handle.net/10191/45096
http://hdl.handle.net/10191/45096b5d80839-07b5-48c3-94c3-e5153ae6dcb0
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本文 (700.9 kB)
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要旨 (217.6 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2016-12-07 | |||||
| タイトル | ||||||
| タイトル | Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer | |||||
| タイトル | ||||||
| タイトル | Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | colorectal cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | myofibroblast | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | muscularis propria | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | prognosis | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 固有筋層における筋線維芽細胞は大腸癌の悪性度に関与する | |||||
| 著者 |
Takatsuna, Masafumi
× Takatsuna, Masafumi |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50897 | |||||
| 姓名 | 高綱, 将史 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Myofibroblasts of colorectal cancer (CRC) have been associated with histopathological factors such as lymph node metastasis, liver metastasis and local recurrence. However, few studies have assessed the association between these malignant traits and the myofibroblast distribution in CRC. We aimed to evaluate the relationship between clinical factors and myofibroblast distribution around CRC invasive lesions. The study included 121 cases of pT3 CRC that were diagnosed at stage II or III. Myofibroblast density of the following three histological layers was measured: the submucosa (SM), muscularis propria (MP) and subserosa (SS). We analyzed the relationship between the clinicopathological factors and myofibroblast density by studying the istopathological features of the three layers. The myofibroblast density of the MP layer was significantly higher in the groups with high-frequency lymphatic and venous invasion than the groups with low-frequency lymphatic (P<0.001) and venous (P<0.01) invasion, respectively. In the positive lymph node metastasis group, the myofibroblast density at the MP layer was significantly higher than that in the negative lymph node metastasis group (P<0.001). The high myofibroblast density group at the MP layer was significantly associated with poor overall survival (P<0.003). Our study indicated that myofibroblasts are a type of cancer-associated fibroblasts and that the myofibroblast distribution contributes to the malignant potential of CRC. Furthermore, we demonstrated that myofibroblasts present at the MP layer play an important role in the malignant potential and poor prognosis of patients with CRC | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第4210号. 学位記番号: 新大院博（医）甲第709号. 学位授与年月日: 平成28年9月20日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ONCOLOGY REPORTS | |||||
| 書誌情報 | 発行日 2016-09-20 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4210号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第709号 | |||||
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Cite as
Takatsuna, Masafumi, 2016, Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer: 新潟大学.
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