WEKO3
アイテム
Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars
http://hdl.handle.net/10191/32172
http://hdl.handle.net/10191/3217235e7ef42-09b3-442d-bf0b-85062153774a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 (1.9 MB)
|
|
|
|
要旨 (237.3 kB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-12-03 | |||||
| タイトル | ||||||
| タイトル | Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars | |||||
| タイトル | ||||||
| タイトル | Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD68 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD163 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD204 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dental pulp | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | macrophage | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mineral trioxide aggregate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pulpotomy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rat (Wistar) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | Mineral Trioxide Aggregateを用いた生活断髄後のラット臼歯歯髄の反応 : M2マクロファージ関連分子陽性細胞の一過性集積 | |||||
| 著者 |
Takei, Erika
× Takei, Erika |
|||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50559 | |||||
| 姓名 | 武井, 絵梨花 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: M2 (alternatively-activated) macrophages are known to participate in wound healing and tissue repair. This study aimed to analyze the temporospatial changes in the distribution and density of M2 macrophage-associated molecule-expressing cells after pulpotomy with mineral trioxide aggregate (MTA) in rat molars, in order to ascertain the role played by M2 macrophages in the healing of MTA-capped pulp tissue. Methods: The maxillary first molars of 8-week-old Wistar rats were pulpotomized and capped with MTA. After 1-14 days, the teeth were examined after hematoxylin-eosin staining or immunoperoxidase staining of CD68 (a general macrophage marker) and M2 macrophage markers (CD163 and CD204). The density of positively-stained cells was enumerated in the surface and inner regions (0 -100 µm and 300-400 µm, respectively, from the wound surface). Results: MTA-capping initially caused mild inflammatory changes and the formation of a degenerative layer, followed by progressive new matrix formation and calcified bridging. At 1-2 days, CD68-, CD163-, and CD204-positive cells started to accumulate beneath the degenerative layer, and the density of these cells was significantly higher in the surface region than in the inner region (P < 0.05). From 7 days onwards, the three types of cells displayed an almost normal distribution beneath the newly dentin-like matrix. Conclusions: After the pulpotomy of rat molars with MTA, M2 macrophage-associated molecule-expressing cells transiently accumulated beneath the degenerative layer under the MTA. This suggests that M2 macrophages participate in the initial phases of the healing of MTA-capped pulp tissue. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（歯学）. 報告番号: 甲第4003号. 学位記番号: 新大院博（歯）甲第316号. 学位授与年月日: 平成27年3月23日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of endodontics. 2014, 40(12), 1983-1988. | |||||
| 書誌情報 | p. 1-25, 発行日 2015-03-23 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.joen.2014.08.012 | |||||
| 権利 | ||||||
| 権利情報 | Copyright(C) 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4003号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（歯）甲第316号 | |||||
