{"_buckets": {"deposit": "6686ca8a-a376-46ed-88a4-53b1c79c4f06"}, "_deposit": {"id": "5595", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5595"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00005595", "sets": ["455", "434"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Mineral Trioxide Aggregateを用いた生活断髄後のラット臼歯歯髄の反応 : M2マクロファージ関連分子陽性細胞の一過性集積"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-03-23", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "25", "bibliographicPageStart": "1", "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2015-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（歯学）"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Introduction: M2 (alternatively-activated) macrophages are known to participate in wound healing and tissue repair. This study aimed to analyze the temporospatial changes in the distribution and density of M2 macrophage-associated molecule-expressing cells after pulpotomy with mineral trioxide aggregate (MTA) in rat molars, in order to ascertain the role played by M2 macrophages in the healing of MTA-capped pulp tissue. Methods: The maxillary first molars of 8-week-old Wistar rats were pulpotomized and capped with MTA. After 1-14 days, the teeth were examined after hematoxylin-eosin staining or immunoperoxidase staining of CD68 (a general macrophage marker) and M2 macrophage markers (CD163 and CD204). The density of positively-stained cells was enumerated in the surface and inner regions (0 -100 µm and 300-400 µm, respectively, from the wound surface). Results: MTA-capping initially caused mild inflammatory changes and the formation of a degenerative layer, followed by progressive new matrix formation and calcified bridging. At 1-2 days, CD68-, CD163-, and CD204-positive cells started to accumulate beneath the degenerative layer, and the density of these cells was significantly higher in the surface region than in the inner region (P \u003c 0.05). From 7 days onwards, the three types of cells displayed an almost normal distribution beneath the newly dentin-like matrix. Conclusions: After the pulpotomy of rat molars with MTA, M2 macrophage-associated molecule-expressing cells transiently accumulated beneath the degenerative layer under the MTA. This suggests that M2 macrophages participate in the initial phases of the healing of MTA-capped pulp tissue.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "学位の種類: 博士（歯学）. 報告番号: 甲第4003号. 学位記番号: 新大院博（歯）甲第316号. 学位授与年月日: 平成27年3月23日", "subitem_description_type": "Other"}, {"subitem_description": "Journal of endodontics. 2014, 40(12), 1983-1988.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博（歯）甲第316号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4003号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "50559", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "武井, 絵梨花"}]}]}, "item_6_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.joen.2014.08.012", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright(C) 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved."}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takei, Erika"}], "nameIdentifiers": [{"nameIdentifier": "50558", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h26ndk316.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/5595/files/h26ndk316.pdf"}, "version_id": "21b09dc9-3257-4e5a-b5d2-aca4564d2765"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h26ndk316_a.pdf", "filesize": [{"value": "237.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 237300.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/5595/files/h26ndk316_a.pdf"}, "version_id": "09390eb1-8970-4a5c-bf35-466296fdaa2e"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "CD68", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD163", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD204", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dental pulp", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macrophage", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mineral trioxide aggregate", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pulpotomy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "rat (Wistar)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars"}, {"subitem_title": "Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "434"], "permalink_uri": "http://hdl.handle.net/10191/32172", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-12-03"}, "publish_date": "2015-12-03", "publish_status": "0", "recid": "5595", "relation": {}, "relation_version_is_last": true, "title": ["Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars"], "weko_shared_id": 2}