{"created":"2021-03-01T06:09:27.489334+00:00","id":5595,"links":{},"metadata":{"_buckets":{"deposit":"6686ca8a-a376-46ed-88a4-53b1c79c4f06"},"_deposit":{"id":"5595","owners":[],"pid":{"revision_id":0,"type":"depid","value":"5595"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00005595","sets":["432:433:434","453:455"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Mineral Trioxide Aggregateを用いた生活断髄後のラット臼歯歯髄の反応 : M2マクロファージ関連分子陽性細胞の一過性集積"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03-23","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"25","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: M2 (alternatively-activated) macrophages are known to participate in wound healing and tissue repair. This study aimed to analyze the temporospatial changes in the distribution and density of M2 macrophage-associated molecule-expressing cells after pulpotomy with mineral trioxide aggregate (MTA) in rat molars, in order to ascertain the role played by M2 macrophages in the healing of MTA-capped pulp tissue. Methods: The maxillary first molars of 8-week-old Wistar rats were pulpotomized and capped with MTA. After 1-14 days, the teeth were examined after hematoxylin-eosin staining or immunoperoxidase staining of CD68 (a general macrophage marker) and M2 macrophage markers (CD163 and CD204). The density of positively-stained cells was enumerated in the surface and inner regions (0 -100 µm and 300-400 µm, respectively, from the wound surface). Results: MTA-capping initially caused mild inflammatory changes and the formation of a degenerative layer, followed by progressive new matrix formation and calcified bridging. At 1-2 days, CD68-, CD163-, and CD204-positive cells started to accumulate beneath the degenerative layer, and the density of these cells was significantly higher in the surface region than in the inner region (P < 0.05). From 7 days onwards, the three types of cells displayed an almost normal distribution beneath the newly dentin-like matrix. Conclusions: After the pulpotomy of rat molars with MTA, M2 macrophage-associated molecule-expressing cells transiently accumulated beneath the degenerative layer under the MTA. This suggests that M2 macrophages participate in the initial phases of the healing of MTA-capped pulp tissue.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（歯学）. 報告番号: 甲第4003号. 学位記番号: 新大院博（歯）甲第316号. 学位授与年月日: 平成27年3月23日","subitem_description_type":"Other"},{"subitem_description":"Journal of endodontics. 2014, 40(12), 1983-1988.","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（歯）甲第316号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4003号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"50559","nameIdentifierScheme":"WEKO"}],"names":[{"name":"武井, 絵梨花"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.joen.2014.08.012","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright(C) 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved."}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takei, Erika"}],"nameIdentifiers":[{"nameIdentifier":"50558","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h26ndk316.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/5595/files/h26ndk316.pdf"},"version_id":"21b09dc9-3257-4e5a-b5d2-aca4564d2765"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h26ndk316_a.pdf","filesize":[{"value":"237.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/5595/files/h26ndk316_a.pdf"},"version_id":"09390eb1-8970-4a5c-bf35-466296fdaa2e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD68","subitem_subject_scheme":"Other"},{"subitem_subject":"CD163","subitem_subject_scheme":"Other"},{"subitem_subject":"CD204","subitem_subject_scheme":"Other"},{"subitem_subject":"dental pulp","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_scheme":"Other"},{"subitem_subject":"mineral trioxide aggregate","subitem_subject_scheme":"Other"},{"subitem_subject":"pulpotomy","subitem_subject_scheme":"Other"},{"subitem_subject":"rat (Wistar)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars"},{"subitem_title":"Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","434"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-03"},"publish_date":"2015-12-03","publish_status":"0","recid":"5595","relation_version_is_last":true,"title":["Initial Transient Accumulation of M2 Macrophage-associated Molecule-expressing Cells after Pulpotomy with Mineral Trioxide Aggregate in Rat Molars"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:38:40.444668+00:00"}