{"_buckets": {"deposit": "71ecb834-44ff-4eff-9b49-2217a084006c"}, "_deposit": {"id": "5394", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5394"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00005394"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Pathological Diversity in Neuromyelitis Optica"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-03-24", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "34", "bibliographicPageStart": "1", "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2014-03-24"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u8996\u795e\u7d4c\u810a\u9ac4\u708e (neuromyelitis optica: NMO) \u306f\u810a\u9ac4\u3068\u8996\u795e\u7d4c\u306b\u75c5\u5909\u306e\u4e3b\u5ea7\u3092\u7f6e\u304f\u4e2d\u67a2\u6027\u708e\u75c7\u6027\u8131\u9ac4\u75be\u60a3\u3067\u3042\u308b. NMO \u3067\u306f\u30a2\u30af\u30a2\u30dd\u30ea\u30f34 (aquaporin-4: AQP4)\u6c34\u30c1\u30e3\u30cd\u30eb\u3092\u6a19\u7684\u3068\u3059\u308b\u81ea\u5df1\u6297\u4f53\u304c\u8840\u6e05\u4e2d\u304b\u3089\u691c\u51fa\u3055\u308c, \u75c5\u7406\u5b66\u7684\u306b\u306f\u5e83\u7bc4\u306aAQP4 \u67d3\u8272\u6027\u4f4e\u4e0b\u3092\u4f34\u3046\u88dc\u4f53\u4ecb\u5728\u6027\u306e\u7834\u58ca\u6027\u708e\u75c7\u6027\u8131\u9ac4\u3092\u8a8d\u3081\u308b. \u3053\u308c\u3089\u306e\u77e5\u898b\u304b\u3089, AQP4 \u6297\u4f53\u306fNMO \u75c5\u5909\u306e\u5f62\u6210\u306b\u304a\u3044\u3066\u4e3b\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b. AQP4 \u306f\u8996\u795e\u7d4c, \u810a\u9ac4\u4ee5\u5916\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u3082\u5e83\u304f\u5206\u5e03\u3057\u3066\u3044\u308b. NMO\u306f\u8996\u795e\u7d4c\u3084\u810a\u9ac4\u306a\u3069\u7279\u5b9a\u306e\u90e8\u4f4d\u306b\u75c5\u5909\u3092\u5448\u3057\u3084\u3059\u3044\u304c, \u65e2\u5b58\u306e\u6982\u5ff5\u3092\u8d8a\u3048\u3066\u591a\u5f69\u306a\u75c5\u5909\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b. NMO \u75c5\u5909\u306e\u5206\u5e03\u3084\u7279\u5fb4\u306e\u5dee\u7570\u306f,AQP4 \u306e\u767a\u73fe\u5206\u5e03\u3060\u3051\u3067\u306f\u8aac\u660e\u3067\u304d\u306a\u3044. \u3053\u306e\u5dee\u7570\u3092\u751f\u3080\u6a5f\u5e8f\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306b,NMO \u75c5\u5909\u306e\u90e8\u4f4d\u3054\u3068\u306e\u7279\u5fb4\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f.\u691c\u7d22\u65b9\u6cd5\u3068\u3057\u3066\u306f, neuromyelitis optica spectrum disorders (NMOsd) \u3068\u3057\u3066, \u305d\u306e\u810a\u9ac4\u306bAQP4 \u306e\u5e83\u7bc4\u306a\u4f4e\u4e0b\u3092\u4f34\u3046\u88dc\u4f53\u4ecb\u5728\u6027\u306e\u7834\u58ca\u6027\u708e\u75c7\u6027\u8131\u9ac4\u304c\u75c5\u7406\u5b66\u7684\u306b\u78ba\u8a8d\u3055\u308c\u305f7 \u75c7\u4f8b, \u591a\u767a\u6027\u786c\u5316\u75c73 \u75c7\u4f8b, \u5bfe\u71674 \u75c7\u4f8b\u306e\u5256\u691c\u8133\u3092\u5bfe\u8c61\u306b,\u810a\u9ac4, \u8996\u795e\u7d4c, \u5927\u8133\u767d\u8cea, \u5927\u8133\u76ae\u8cea, \u8133\u5e79, \u5c0f\u8133\u306b\u3064\u3044\u3066\u75c5\u7406\u5b66\u7684\u691c\u7d22\u3092\u884c\u3063\u305f. \u305d\u306e\u7d50\u679c, NMOsd \u306e\u8996\u795e\u7d4c, \u5927\u8133\u767d\u8cea, \u8133\u5e79\u306e\u75c5\u5909\u3067\u306f\u810a\u9ac4\u75c5\u5909\u3068\u540c\u69d8\u306bAQP4 \u306e\u5e83\u7bc4\u306a\u4f4e\u4e0b\u3092\u4f34\u3046\u88dc\u4f53\u4ecb\u5728\u6027\u306e\u7834\u58ca\u6027\u708e\u75c7\u6027\u8131\u9ac4\u304c\u89b3\u5bdf\u3055\u308c\u305f. NMOsd\u306e\u5927\u8133\u76ae\u8cea\u3067\u306f, \u88dc\u4f53\u306e\u4ecb\u5728\u3084\u7834\u58ca\u6027\u708e\u75c7\u6027\u8131\u9ac4\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u304c, \u795e\u7d4c\u7d30\u80de\u8131\u843d\u3068\u76ae\u8cea\u7b2cI \u5c64\u306b\u9650\u5c40\u3057\u305fAQP4 \u67d3\u8272\u6027\u4f4e\u4e0b\u3092\u8a8d\u3081\u305f. \u5ef6\u9ac4\u6700\u5f8c\u91ce\u306e\u75c5\u5909\u3067\u306f,\u9078\u629e\u7684\u306aAQP4 \u55aa\u5931\u3068\u88dc\u4f53\u6c88\u7740\u3092\u8a8d\u3081\u305f\u304c, \u7d44\u7e54\u69cb\u7bc9\u306e\u7834\u58ca\u306f\u660e\u3089\u304b\u3067\u306a\u304b\u3063\u305f.NMOsd \u306e\u5c0f\u8133\u3067\u306f\u795e\u7d4c\u7d30\u80de\u8131\u843d\u3084\u8131\u9ac4, AQP4 \u67d3\u8272\u6027\u306e\u5909\u5316, \u708e\u75c7\u3084\u6d3b\u6027\u5316\u88dc\u4f53\u306e\u6c88\u7740\u306a\u3069\u306e\u75c5\u7406\u5909\u5316\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f.\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089, NMO \u3067\u306f\u540c\u4e00\u75c7\u4f8b\u306e\u4e2d\u67a2\u795e\u7d4c\u5185\u306b\u304a\u3044\u3066\u3082, \u90e8\u4f4d\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u88dc\u4f53\u3084AQP4 \u306e\u75c5\u7406\u5909\u5316\u304c\u8a8d\u3081\u3089\u308c, \u8996\u795e\u7d4c\u810a\u9ac4\u578b, \u5927\u8133\u76ae\u8cea\u578b, \u5ef6\u9ac4\u6700\u5f8c\u91ce\u578b\u306e3 \u578b\u306b\u5206\u3051\u3089\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f. AQP4 \u6297\u4f53\u304c\u75c5\u5909\u3092\u5f62\u6210\u3059\u308b\u6a5f\u5e8f\u3068\u3057\u3066,\u88dc\u4f53\u4f9d\u5b58\u6027\u306e\u7d30\u80de\u969c\u5bb3, \u6297\u4f53\u4f9d\u5b58\u6027\u306e\u7d30\u80de\u969c\u5bb3, AQP4 \u5185\u5728\u5316\u306a\u3069\u3067\u306f\u3053\u306e3 \u578b\u306e\u9055\u3044\u306f\u8aac\u660e\u3067\u304d\u305a, AQP4 \u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u306e\u9055\u3044\u3084\u88dc\u4f53\u5236\u5fa1\u56e0\u5b50\u306e\u5171\u767a\u73fe\u72b6\u614b\u306e\u9055\u3044\u3092\u60f3\u5b9a\u3057\u3066, \u4eca\u5f8c\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u5b66\u4f4d\u306e\u7a2e\u985e: \u535a\u58eb\uff08\u533b\u5b66\uff09. \u5831\u544a\u756a\u53f7: \u7532\u7b2c3832\u53f7. \u5b66\u4f4d\u8a18\u756a\u53f7: \u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c572\u53f7. \u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5: \u5e73\u621026\u5e743\u670824\u65e5", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": "\u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c572\u53f7", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101\u7532\u7b2c3832\u53f7"}]}, "item_6_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "50200", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Arakawa, Musashi"}]}]}, "item_6_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u5927\u5b66"}]}, "item_6_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u8352\u5ddd, \u6b66\u8535"}], "nameIdentifiers": [{"nameIdentifier": "50199", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h25nmk572.pdf", "filesize": [{"value": "354.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 354700000.0, "url": {"label": "\u672c\u6587", "url": "https://niigata-u.repo.nii.ac.jp/record/5394/files/h25nmk572.pdf"}, "version_id": "c0d51c96-bf32-4b6b-bbc5-a44735d0be46"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h25nmk572_a.pdf", "filesize": [{"value": "187.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 187200.0, "url": {"label": "\u8981\u65e8", "url": "https://niigata-u.repo.nii.ac.jp/record/5394/files/h25nmk572_a.pdf"}, "version_id": "dcfcd220-5ad1-4ff8-8d11-5b5886f04fec"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "\u8996\u795e\u7d4c\u810a\u9ac4\u708e", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a2\u30af\u30a2\u30dd\u30ea\u30f34", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u88dc\u4f53", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5927\u8133\u76ae\u8cea", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5ef6\u9ac4\u6700\u5f8c\u91ce", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "\u8996\u795e\u7d4c\u810a\u9ac4\u708e\u306b\u304a\u3051\u308b\u75c5\u7406\u6240\u898b\u306e\u591a\u69d8\u6027\u306b\u3064\u3044\u3066", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u8996\u795e\u7d4c\u810a\u9ac4\u708e\u306b\u304a\u3051\u308b\u75c5\u7406\u6240\u898b\u306e\u591a\u69d8\u6027\u306b\u3064\u3044\u3066"}, {"subitem_title": "\u8996\u795e\u7d4c\u810a\u9ac4\u708e\u306b\u304a\u3051\u308b\u75c5\u7406\u6240\u898b\u306e\u591a\u69d8\u6027\u306b\u3064\u3044\u3066", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "471/561/562"], "permalink_uri": "http://hdl.handle.net/10191/27336", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2014-05-22"}, "publish_date": "2014-05-22", "publish_status": "0", "recid": "5394", "relation": {}, "relation_version_is_last": true, "title": ["\u8996\u795e\u7d4c\u810a\u9ac4\u708e\u306b\u304a\u3051\u308b\u75c5\u7406\u6240\u898b\u306e\u591a\u69d8\u6027\u306b\u3064\u3044\u3066"], "weko_shared_id": 2}