ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "d50b2a0e-fb09-47ea-b849-60b0bb24a6ab"}, "_deposit": {"id": "34036", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "34036"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00034036"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u8ef8\u7d22\u4f38\u9577\u30fb\u518d\u751f\u306b\u95a2\u4e0e\u3059\u308b\u5fae\u5c0f\u7ba1\u91cd\u5408\u4fc3\u9032\u30bf\u30f3\u30d1\u30af\u8ceaMAP 1B\u306e\u30ea\u30f3\u9178\u5316\u90e8\u4f4d"}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2020-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb(\u533b\u5b66)"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The growth cone is a specialized structure that forms at the tip of extending axons in developing and regenerating neurons. This structure is essential for accurate synaptogenesis at developmental stages, and is also involved in plasticity-dependent synaptogenesis and axon regeneration in the mature brain. Thus, understanding the molecular mechanisms utilized by growth cones is indispensable to understanding neuronal network formation and rearrangement. Phosphorylation is the most important and commonly utilized protein modification in signal transduction. We previously identified microtubule-associated protein 1B (MAP 1B) as the most frequently phosphorylated protein among ~ 1200 phosphorylated proteins. MAP 1B has more than 10 phosphorylation sites that were present more than 50 times among these 1200 proteins. Here, we produced phospho-specific antibodies against phosphorylated serines at positions 25 and 1201 of MAP 1B that specifically recognize growing axons both in cultured neurons and in vivo in various regions of the embryonic brain. Following sciatic nerve injury, immunoreactivity with each antibody increased compared to the sham operated group. Experiments with transected and sutured nerves revealed that regenerating axons were specifically recognized by these antibodies. These results suggest that these MAP 1B phosphorylation sites are specifically involved in axon growth and that phospho-specific antibodies against MAP 1B are useful markers of growing/regenerating axons.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "Molecular Brain. 2019, 12, 93.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": "\u65b0\u5927\u9662\u535a(\u533b)\u7532\u7b2c945\u53f7", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101\u7532\u7b2c4711\u53f7"}]}, "item_6_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "178071", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "\u77f3\u5ddd, \u88d5\u4e5f"}]}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1186/s13041-019-0510-z", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ishikawa, Yuya"}], "nameIdentifiers": [{"nameIdentifier": "178070", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-08-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r1nmk945.pdf", "filesize": [{"value": "6.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 6000000.0, "url": {"label": "\u672c\u6587", "url": "https://niigata-u.repo.nii.ac.jp/record/34036/files/r1nmk945.pdf"}, "version_id": "369d0949-22d5-44b5-afbb-5e557910f964"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-08-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r1nmk945_a.pdf", "filesize": [{"value": "570.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 570800.0, "url": {"label": "\u8981\u65e8", "url": "https://niigata-u.repo.nii.ac.jp/record/34036/files/r1nmk945_a.pdf"}, "version_id": "6fb72a2a-431f-4ab2-8955-4df92fee87df"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Phosphorylation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MAP 1B", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Development", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Growth cone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Axon regeneration", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Phosphorylation sites of microtubuleassociated protein 1B (MAP 1B) are involved in axon growth and regeneration", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Phosphorylation sites of microtubuleassociated protein 1B (MAP 1B) are involved in axon growth and regeneration"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "471/561/562"], "permalink_uri": "http://hdl.handle.net/10191/00051834", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2020-08-31"}, "publish_date": "2020-08-31", "publish_status": "0", "recid": "34036", "relation": {}, "relation_version_is_last": true, "title": ["Phosphorylation sites of microtubuleassociated protein 1B (MAP 1B) are involved in axon growth and regeneration"], "weko_shared_id": null}
  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Phosphorylation sites of microtubuleassociated protein 1B (MAP 1B) are involved in axon growth and regeneration

http://hdl.handle.net/10191/00051834
281449b3-c876-4b08-83d5-e06e99b0f113
名前 / ファイル ライセンス アクション
r1nmk945.pdf 本文 (6.0 MB)
r1nmk945_a.pdf 要旨 (570.8 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-08-31
タイトル
タイトル Phosphorylation sites of microtubuleassociated protein 1B (MAP 1B) are involved in axon growth and regeneration
言語
言語 eng
キーワード
主題Scheme Other
主題 Phosphorylation
キーワード
主題Scheme Other
主題 MAP 1B
キーワード
主題Scheme Other
主題 Development
キーワード
主題Scheme Other
主題 Growth cone
キーワード
主題Scheme Other
主題 Axon regeneration
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 軸索伸長・再生に関与する微小管重合促進タンパク質MAP 1Bのリン酸化部位
著者 Ishikawa, Yuya

× Ishikawa, Yuya

WEKO 178070

Ishikawa, Yuya

Search repository
著者別名
識別子
識別子 178071
識別子Scheme WEKO
姓名
姓名 石川, 裕也
抄録
内容記述タイプ Abstract
内容記述 The growth cone is a specialized structure that forms at the tip of extending axons in developing and regenerating neurons. This structure is essential for accurate synaptogenesis at developmental stages, and is also involved in plasticity-dependent synaptogenesis and axon regeneration in the mature brain. Thus, understanding the molecular mechanisms utilized by growth cones is indispensable to understanding neuronal network formation and rearrangement. Phosphorylation is the most important and commonly utilized protein modification in signal transduction. We previously identified microtubule-associated protein 1B (MAP 1B) as the most frequently phosphorylated protein among ~ 1200 phosphorylated proteins. MAP 1B has more than 10 phosphorylation sites that were present more than 50 times among these 1200 proteins. Here, we produced phospho-specific antibodies against phosphorylated serines at positions 25 and 1201 of MAP 1B that specifically recognize growing axons both in cultured neurons and in vivo in various regions of the embryonic brain. Following sciatic nerve injury, immunoreactivity with each antibody increased compared to the sham operated group. Experiments with transected and sutured nerves revealed that regenerating axons were specifically recognized by these antibodies. These results suggest that these MAP 1B phosphorylation sites are specifically involved in axon growth and that phospho-specific antibodies against MAP 1B are useful markers of growing/regenerating axons.
内容記述
内容記述タイプ Other
内容記述 Molecular Brain. 2019, 12, 93.
DOI
関連識別子
識別子タイプ DOI
関連識別子 info:doi/10.1186/s13041-019-0510-z
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2020-03-23
学位授与番号
学位授与番号 13101甲第4711号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第945号
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 07:53:29.358759
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio