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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Development of a mouse nerve-transfer model for brachial plexus injury

http://hdl.handle.net/10191/00051818
http://hdl.handle.net/10191/00051818
cdef7ca6-320f-41b0-bdfc-63f0a241e22f
名前 / ファイル ライセンス アクション
r1nmk929.pdf 本文 (15.9 MB)
r1nmk929_a.pdf 要旨 (572.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-08-31
タイトル
タイトル Development of a mouse nerve-transfer model for brachial plexus injury
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 腕神経損傷に対するマウス神経移行術モデルの作成
著者 Wakatsuki, Hanako

× Wakatsuki, Hanako

WEKO 178039

Wakatsuki, Hanako

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著者別名
識別子 178040
識別子Scheme WEKO
姓名 若槻, 華子
抄録
内容記述タイプ Abstract
内容記述 Nerve transfer involves the use of a portion of a healthy nerve to repair an injured nerve, and the process has been used to alleviate traumatic brachial plexus injuries in humans. Study of the neural mechanisms that occur during nerve transfer, however, requires the establishment of reliable experimental models. In this study, we developed an ulnar-musculocutaneous nerve-transfer model wherein the biceps muscle of a mouse was re-innervated using a donor ulnar nerve. Similar muscle action potentials were detected in both the end-to-end suture of the transected nerve (correct-repair) group and the ulnar-musculocutaneous nerve-transfer group. Also, re-innervated acetylcholine receptor (AChR) clusters and muscle spindles were observed in both procedures. There were fewer re-innervated AChR clusters in the nerve transfer group than in the correct repair group at 4weeks, but the numbers were equal at 24 weeks following surgery. Thus, our ulnar-musculocutaneous nerve-transfer model allowed physiological and morphological evaluation for re-innervation process in mice and revealed the delay of this process during nerve transfer procedure. This model will provide great opportunities to study regeneration, re-innervation, and functional recovery induced via nerve transfer procedures.
内容記述
内容記述タイプ Other
内容記述 Biomedical Research. 2019, 40(3), 115-123.
DOI
識別子タイプ DOI
関連識別子 info:doi/10.2220/biomedres.40.115
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2020-03-23
学位授与番号
学位授与番号 13101甲第4695号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第929号
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