{"created":"2021-03-01T06:40:28.020376+00:00","id":34020,"links":{},"metadata":{"_buckets":{"deposit":"94afc71a-3e78-474f-8b13-3aa8f605764e"},"_deposit":{"id":"34020","owners":[],"pid":{"revision_id":0,"type":"depid","value":"34020"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00034020","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"腕神経損傷に対するマウス神経移行術モデルの作成"}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Nerve transfer involves the use of a portion of a healthy nerve to repair an injured nerve, and the　process has been used to alleviate traumatic brachial plexus injuries in humans. Study of the neural mechanisms that occur during nerve transfer, however, requires the establishment of reliable　experimental models. In this study, we developed an ulnar-musculocutaneous nerve-transfer model　wherein the biceps muscle of a mouse was re-innervated using a donor ulnar nerve. Similar muscle　action potentials were detected in both the end-to-end suture of the transected nerve (correct-repair) group and the ulnar-musculocutaneous nerve-transfer group. Also, re-innervated acetylcholine receptor (AChR) clusters and muscle spindles were observed in both procedures. There were　fewer re-innervated AChR clusters in the nerve transfer group than in the correct repair group at 4weeks, but the numbers were equal at 24 weeks following surgery. Thus, our ulnar-musculocutaneous nerve-transfer model allowed physiological and morphological evaluation for re-innervation　process in mice and revealed the delay of this process during nerve transfer procedure. This model will provide great opportunities to study regeneration, re-innervation, and functional recovery　induced via nerve transfer procedures.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Biomedical Research. 2019, 40(3), 115-123.","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博(医)甲第929号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4695号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"178040","nameIdentifierScheme":"WEKO"}],"names":[{"name":"若槻, 華子"}]}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.2220/biomedres.40.115","subitem_relation_type_select":"DOI"}}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wakatsuki, Hanako"}],"nameIdentifiers":[{"nameIdentifier":"178039","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-31"}],"displaytype":"detail","filename":"r1nmk929.pdf","filesize":[{"value":"15.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/34020/files/r1nmk929.pdf"},"version_id":"8e94f649-1f52-41f6-b422-53ca259b1543"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-31"}],"displaytype":"detail","filename":"r1nmk929_a.pdf","filesize":[{"value":"572.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/34020/files/r1nmk929_a.pdf"},"version_id":"09eee321-64ba-4145-8aba-f0f94431d9f0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Development of a mouse nerve-transfer model for brachial plexus injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of a mouse nerve-transfer model for brachial plexus injury"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-31"},"publish_date":"2020-08-31","publish_status":"0","recid":"34020","relation_version_is_last":true,"title":["Development of a mouse nerve-transfer model for brachial plexus injury"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T04:04:21.068206+00:00"}