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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases

http://hdl.handle.net/10191/00051651
http://hdl.handle.net/10191/00051651
e8287df8-e57b-4472-a0cb-10b6e1d260d9
名前 / ファイル ライセンス アクション
r1nmk887.pdf 本文 (2.3 MB)
r1nmk887_a.pdf 要旨 (644.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-06-10
タイトル
タイトル CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases
言語
言語 eng
キーワード
主題Scheme Other
主題 adult T-cell leukemia/lymphoma
キーワード
主題Scheme Other
主題 cell adhesion molecule 1
キーワード
主題Scheme Other
主題 cutaneous T-cell lymphoma
キーワード
主題Scheme Other
主題 mycosis fungoides
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 早期菌状息肉症の診断におけるCADM1の有用性についての検討
著者 Yuki, Akihiko

× Yuki, Akihiko

WEKO 177829

Yuki, Akihiko

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著者別名
識別子 177830
識別子Scheme WEKO
姓名 結城, 明彦
抄録
内容記述タイプ Abstract
内容記述 Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 gene (CADM1), which was initially identified as a tumor suppressor gene in human non-small cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma. Objective: We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF. Methods: We conducted a retrospective study by using immunohistochemical staining and confirmed the expression of CADM1 in MF. In addition, we compared CADM1 messenger RNA expression in microdissected MF samples and ISD samples. Results: In the overall study period, 55 of 58 MF samples (94.8%) stained positive for CADM1. None of the 50 ISD samples showed positive reactivity (P<.0001). We found CADM1 messenger RNA expression in the intradermal lymphocytes of patients with MF but not in those of patients with an ISD. Limitations: We did not conduct a validation study for MF cases in other institutions. Conclusions: CADM1-positive cells can be identified in early stages with fewer infiltrating cells and may be useful as a diagnostic marker for early-stage MF. (J Am Acad Dermatol 2018;79:1039-46.)
内容記述
内容記述タイプ Other
内容記述 J Am Acad Dermatol. 2018, 79(6), 1039-1046.
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.jaad.2018.06.025
権利
権利情報 【○!C】 2018 by the American Academy of Dermatology, Inc.
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2019-09-20
学位授与番号
学位授与番号 13101甲第4627号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第887号
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