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CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases
http://hdl.handle.net/10191/00051651
http://hdl.handle.net/10191/00051651e8287df8-e57b-4472-a0cb-10b6e1d260d9
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本文 (2.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2020-06-10 | |||||
| タイトル | ||||||
| タイトル | CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | adult T-cell leukemia/lymphoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cell adhesion molecule 1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cutaneous T-cell lymphoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mycosis fungoides | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 早期菌状息肉症の診断におけるCADM1の有用性についての検討 | |||||
| 著者 |
Yuki, Akihiko
× Yuki, Akihiko |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 177830 | |||||
| 姓名 | 結城, 明彦 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 gene (CADM1), which was initially identified as a tumor suppressor gene in human non-small cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma. Objective: We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF. Methods: We conducted a retrospective study by using immunohistochemical staining and confirmed the expression of CADM1 in MF. In addition, we compared CADM1 messenger RNA expression in microdissected MF samples and ISD samples. Results: In the overall study period, 55 of 58 MF samples (94.8%) stained positive for CADM1. None of the 50 ISD samples showed positive reactivity (P<.0001). We found CADM1 messenger RNA expression in the intradermal lymphocytes of patients with MF but not in those of patients with an ISD. Limitations: We did not conduct a validation study for MF cases in other institutions. Conclusions: CADM1-positive cells can be identified in early stages with fewer infiltrating cells and may be useful as a diagnostic marker for early-stage MF. (J Am Acad Dermatol 2018;79:1039-46.) | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | J Am Acad Dermatol. 2018, 79(6), 1039-1046. | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.jaad.2018.06.025 | |||||
| 権利 | ||||||
| 権利情報 | 【○!C】 2018 by the American Academy of Dermatology, Inc. | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2019-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4627号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第887号 | |||||
