{"_buckets": {"deposit": "ec428c6f-9485-4201-b5c4-046048a15b7a"}, "_deposit": {"id": "33843", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "33843"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00033843", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "早期菌状息肉症の診断におけるCADM1の有用性についての検討"}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2019-09-20"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 gene (CADM1), which was initially identified as a tumor suppressor gene in human non-small cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma. Objective: We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF. Methods: We conducted a retrospective study by using immunohistochemical staining and confirmed the expression of CADM1 in MF. In addition, we compared CADM1 messenger RNA expression in microdissected MF samples and ISD samples. Results: In the overall study period, 55 of 58 MF samples (94.8%) stained positive for CADM1. None of the 50 ISD samples showed positive reactivity (P\u003c.0001). We found CADM1 messenger RNA expression in the intradermal lymphocytes of patients with MF but not in those of patients with an ISD. Limitations: We did not conduct a validation study for MF cases in other institutions. Conclusions: CADM1-positive cells can be identified in early stages with fewer infiltrating cells and may be useful as a diagnostic marker for early-stage MF. (J Am Acad Dermatol 2018;79:1039-46.)", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "J Am Acad Dermatol. 2018, 79(6), 1039-1046.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博（医）甲第887号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4627号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "177830", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "結城, 明彦"}]}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.jaad.2018.06.025", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "【○!C】 2018 by the American Academy of Dermatology, Inc."}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yuki, Akihiko"}], "nameIdentifiers": [{"nameIdentifier": "177829", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r1nmk887.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2300000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/33843/files/r1nmk887.pdf"}, "version_id": "c8ea1811-9db4-4f4a-9383-19d245f17d22"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r1nmk887_a.pdf", "filesize": [{"value": "644.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 644100.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/33843/files/r1nmk887_a.pdf"}, "version_id": "22c04b51-1969-4101-baad-6980dfaa7bd1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "adult T-cell leukemia/lymphoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cell adhesion molecule 1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cutaneous T-cell lymphoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mycosis fungoides", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/00051651", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-06-10"}, "publish_date": "2020-06-10", "publish_status": "0", "recid": "33843", "relation": {}, "relation_version_is_last": true, "title": ["CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases"], "weko_shared_id": 2}