{"created":"2021-03-01T06:40:16.640108+00:00","id":33843,"links":{},"metadata":{"_buckets":{"deposit":"ec428c6f-9485-4201-b5c4-046048a15b7a"},"_deposit":{"id":"33843","owners":[],"pid":{"revision_id":0,"type":"depid","value":"33843"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00033843","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"早期菌状息肉症の診断におけるCADM1の有用性についての検討"}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-09-20"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 gene (CADM1), which was initially identified as a tumor suppressor gene in human non-small cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma. Objective: We investigated CADM1 expression in MF neoplastic cells, especially during early stages, and evaluated its usefulness as a diagnostic marker for MF. Methods: We conducted a retrospective study by using immunohistochemical staining and confirmed the expression of CADM1 in MF. In addition, we compared CADM1 messenger RNA expression in microdissected MF samples and ISD samples. Results: In the overall study period, 55 of 58 MF samples (94.8%) stained positive for CADM1. None of the 50 ISD samples showed positive reactivity (P<.0001). We found CADM1 messenger RNA expression in the intradermal lymphocytes of patients with MF but not in those of patients with an ISD. Limitations: We did not conduct a validation study for MF cases in other institutions. Conclusions: CADM1-positive cells can be identified in early stages with fewer infiltrating cells and may be useful as a diagnostic marker for early-stage MF. (J Am Acad Dermatol 2018;79:1039-46.)","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"J Am Acad Dermatol. 2018, 79(6), 1039-1046.","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第887号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4627号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"177830","nameIdentifierScheme":"WEKO"}],"names":[{"name":"結城, 明彦"}]}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.jaad.2018.06.025","subitem_relation_type_select":"DOI"}}]},"item_6_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"【○!C】 2018 by the American Academy of Dermatology, Inc."}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yuki, Akihiko"}],"nameIdentifiers":[{"nameIdentifier":"177829","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-10"}],"displaytype":"detail","filename":"r1nmk887.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/33843/files/r1nmk887.pdf"},"version_id":"c8ea1811-9db4-4f4a-9383-19d245f17d22"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-10"}],"displaytype":"detail","filename":"r1nmk887_a.pdf","filesize":[{"value":"644.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/33843/files/r1nmk887_a.pdf"},"version_id":"22c04b51-1969-4101-baad-6980dfaa7bd1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adult T-cell leukemia/lymphoma","subitem_subject_scheme":"Other"},{"subitem_subject":"cell adhesion molecule 1","subitem_subject_scheme":"Other"},{"subitem_subject":"cutaneous T-cell lymphoma","subitem_subject_scheme":"Other"},{"subitem_subject":"mycosis fungoides","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-06-10"},"publish_date":"2020-06-10","publish_status":"0","recid":"33843","relation_version_is_last":true,"title":["CADM1 is a diagnostic marker in early-stage mycosis fungoides : Multicenter study of 58 cases"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T04:04:04.492943+00:00"}