ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "9c4494a9-3507-46f9-8a56-1b15fe16f347"}, "_deposit": {"id": "32103", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "32103"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00032103", "sets": ["455", "434"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "自己溶菌に伴い漏出する肺炎球菌のDNA結合タンパク質は,TLR4を介して炎症性サイトカインの産生を促進する"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "22", "bibliographicPageStart": "14", "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2019-03-25"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(歯学)"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Streptococcus pneumoniae is a leading cause of bacterial pneumonia. Our previous study suggested that S.pneumoniae autolysis-dependently releases intracellular pneumolysin, which subsequently leads to lung injury. In this study, we hypothesized that pneumococcal autolysis induces the leakage of additional intracellular molecules that could increase the pathogenicity of S. pneumoniae. Liquid chromatography tandem-mass spectrometry analysis identified that chaperone protein DnaK, elongation factor Tu (EF-Tu), and glyceraldehyde-3- phosphate dehydrogenase (GAPDH) were released with pneumococcal DNA by autolysis. We demonstrated that recombinant (r) DnaK, rEF-Tu, and rGAPDH induced significantly higher levels of interleukin-6 and tumor necrosis factor production in peritoneal macrophages and THP-1-derived macrophage-like cells via toll-like receptor 4. Furthermore, the DNA-binding activity of these proteins was confirmed by surface plasmon resonance assay. We demonstrated that pneumococcal DnaK, EF-Tu, and GAPDH induced the production of proinflammatory cytokines in macrophages, and might cause host tissue damage and affect the development of pneumococcal diseases.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "学位の種類: 博士(歯学). 報告番号: 甲第4568号. 学位記番号: 新大院博(歯)甲第417号. 学位授与年月日: 平成31年3月25日", "subitem_description_type": "Other"}, {"subitem_description": "Cellular Immunology. 2018, 325, 14-22.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(歯)甲第417号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4568号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "175224", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "永井, 康介"}]}]}, "item_6_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.cellimm.2018.01.006", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nagai, Kosuke"}], "nameIdentifiers": [{"nameIdentifier": "175223", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h30ndk417.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/32103/files/h30ndk417.pdf"}, "version_id": "e2b5a44b-0f59-440a-975e-135b1c606051"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h30ndk417_a.pdf", "filesize": [{"value": "263.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 263100.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/32103/files/h30ndk417_a.pdf"}, "version_id": "e9db8b00-a4fd-4f0a-bea8-2816290957b3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Streptococcus pneumoniae", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Autolysis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DNA-binding protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DnaK", "subitem_subject_scheme": "Other"}, {"subitem_subject": "EF-Tu", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GAPDH", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TLR4", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4"}, {"subitem_title": "Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "434"], "permalink_uri": "http://hdl.handle.net/10191/51346", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-07-09"}, "publish_date": "2019-07-09", "publish_status": "0", "recid": "32103", "relation": {}, "relation_version_is_last": true, "title": ["Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4"], "weko_shared_id": 2}
  1. 260 大学院医歯学総合研究科(歯)
  2. 60 博士学位論文
  3. 10 博士学位論文
  1. 0 資料タイプ別
  2. 02 学位論文

Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4

http://hdl.handle.net/10191/51346
http://hdl.handle.net/10191/51346
ed8e51f6-d022-44d7-b764-9677cb748eb9
名前 / ファイル ライセンス アクション
h30ndk417.pdf 本文 (1.3 MB)
h30ndk417_a.pdf 要旨 (263.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-07-09
タイトル
タイトル Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4
タイトル
言語 en
タイトル Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4
言語
言語 eng
キーワード
主題Scheme Other
主題 Streptococcus pneumoniae
キーワード
主題Scheme Other
主題 Autolysis
キーワード
主題Scheme Other
主題 DNA-binding protein
キーワード
主題Scheme Other
主題 DnaK
キーワード
主題Scheme Other
主題 EF-Tu
キーワード
主題Scheme Other
主題 GAPDH
キーワード
主題Scheme Other
主題 TLR4
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 自己溶菌に伴い漏出する肺炎球菌のDNA結合タンパク質は,TLR4を介して炎症性サイトカインの産生を促進する
著者 Nagai, Kosuke

× Nagai, Kosuke

WEKO 175223

Nagai, Kosuke

Search repository
著者別名
識別子 175224
識別子Scheme WEKO
姓名 永井, 康介
抄録
内容記述タイプ Abstract
内容記述 Streptococcus pneumoniae is a leading cause of bacterial pneumonia. Our previous study suggested that S.pneumoniae autolysis-dependently releases intracellular pneumolysin, which subsequently leads to lung injury. In this study, we hypothesized that pneumococcal autolysis induces the leakage of additional intracellular molecules that could increase the pathogenicity of S. pneumoniae. Liquid chromatography tandem-mass spectrometry analysis identified that chaperone protein DnaK, elongation factor Tu (EF-Tu), and glyceraldehyde-3- phosphate dehydrogenase (GAPDH) were released with pneumococcal DNA by autolysis. We demonstrated that recombinant (r) DnaK, rEF-Tu, and rGAPDH induced significantly higher levels of interleukin-6 and tumor necrosis factor production in peritoneal macrophages and THP-1-derived macrophage-like cells via toll-like receptor 4. Furthermore, the DNA-binding activity of these proteins was confirmed by surface plasmon resonance assay. We demonstrated that pneumococcal DnaK, EF-Tu, and GAPDH induced the production of proinflammatory cytokines in macrophages, and might cause host tissue damage and affect the development of pneumococcal diseases.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(歯学). 報告番号: 甲第4568号. 学位記番号: 新大院博(歯)甲第417号. 学位授与年月日: 平成31年3月25日
内容記述
内容記述タイプ Other
内容記述 Cellular Immunology. 2018, 325, 14-22.
書誌情報 p. 14-22, 発行日 2019-03-25
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.cellimm.2018.01.006
著者版フラグ
値 ETD
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2019-03-25
学位授与番号
学位授与番号 13101甲第4568号
学位記番号
内容記述タイプ Other
内容記述 新大院博(歯)甲第417号
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 08:47:55.364384
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3