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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

C-terminal intrinsically disordered region-dependent organization of the mycobacterial genome by a histone-like protein

http://hdl.handle.net/10191/50776
http://hdl.handle.net/10191/50776
9eaca8ca-f4c1-499b-8cdc-778fc406cac5
名前 / ファイル ライセンス アクション
h30nmk840.pdf 本文 (5.3 MB)
h30nmk840_a.pdf 要旨 (521.5 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-11-29
タイトル
タイトル C-terminal intrinsically disordered region-dependent organization of the mycobacterial genome by a histone-like protein
タイトル
言語 en
タイトル C-terminal intrinsically disordered region-dependent organization of the mycobacterial genome by a histone-like protein
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル カルボキシターミナルの天然変性領域に依存した抗酸菌ヒストン様蛋白質による抗酸菌ゲノムの構造形成
著者 Savitskaya, Anna

× Savitskaya, Anna

WEKO 175091

Savitskaya, Anna

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抄録
内容記述タイプ Abstract
内容記述 The architecture of the genome influences the functions of DNA from bacteria to eukaryotes. Intrinsically disordered regions (IDR) of eukaryotic histones have pivotal roles in various processes of gene expression. IDR is rare in bacteria, but interestingly, mycobacteria produce a unique histone-like protein, MDP1 that contains a long C-terminal IDR. Here we analyzed the role of IDR in MDP1 function. By employing Mycobacterium smegmatis that inducibly expresses MDP1 or its IDR-deficient mutant, we observed that MDP1 induces IDR-dependent DNA compaction. MDP1-IDR is also responsible for the induction of growth arrest and tolerance to isoniazid, a front line tuberculosis drug that kills growing but not growth-retardated mycobacteria. We demonstrated that MDP1-deficiency and conditional knock out of MDP1 cause spreading of the M. smegmatis genome in the stationary phase. This study thus demonstrates for the first time a C-terminal region-dependent organization of the genome architecture by MDP1, implying the significance of IDR in the function of bacterial histone-like protein.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4503号. 学位記番号: 新大院博(医)甲第840号. 学位授与年月日: 平成30年9月20日
内容記述
内容記述タイプ Other
内容記述 Scientific Reports. 2018, 8, 8197.
書誌情報 発行日 2018-09-20
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1038/s41598-018-26463-9
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2018-09-20
学位授与番号
学位授与番号 13101甲第4503号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第840号
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