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In this study, we addressed whether p70S6 kinase\uff08p70S6K\uff09, a main target of the anti-cancer agent rapamycin, is involved in the clinicopathological factors in NASH-related HCC. Methods: HCC tissue samples were obtained from 22\u3000NASH patients with radical surgical treatment. Phosphorylation level of p70S6K was analyzed by immunohistochemical analysis, and the correlation with the clinicopathological factors were examined. Results: Phosphorylated p70S6K was detected in 54.5%\uff0812/22\uff09of NASH-related HCCs. The levels of phosphop70S6K were correlated with histological grade of HCC\uff08p = 0.047\uff09, but not with clinical factors. Phosphorylation of p70S6K was correlated with increased cancer recurrence after 3 years of the treatment\uff08p= 0.045\uff09. Conclusion: Phosphorylation level of p70S6K was correlated with cancer recurrence of NASH-related HCC. Rapamycin might be a useful agent for treating NASH-associated HCC.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "164518", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Matsuda, Yasunobu"}]}, {"nameIdentifiers": [{"nameIdentifier": "164519", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Wakai, Toshifumi"}]}, {"nameIdentifiers": [{"nameIdentifier": "164520", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hirose, Yuki"}]}, {"nameIdentifiers": [{"nameIdentifier": "164521", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sakata, Jun"}]}, {"nameIdentifiers": [{"nameIdentifier": "164522", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kobayashi, Takashi"}]}, {"nameIdentifiers": [{"nameIdentifier": "164523", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Osawa, Mami"}]}, {"nameIdentifiers": [{"nameIdentifier": "164524", 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