{"created":"2021-03-01T06:34:24.239737+00:00","id":28577,"links":{},"metadata":{"_buckets":{"deposit":"e092e658-5261-4fbb-9935-4d5c19b8d089"},"_deposit":{"id":"28577","owners":[],"pid":{"revision_id":0,"type":"depid","value":"28577"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00028577","sets":["453:456","506:1624:1625:1630"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"p70S6 kinase is activated in non-alcoholic steatohepatitis-related hepatocellular carcinoma"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"56","bibliographicPageStart":"51","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"新潟大学保健学雑誌"},{"bibliographic_title":"新潟大学保健学雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】非アルコール性脂肪肝炎（NASH）は，近年急速に増加している原因不明の肝疾患である。本研究では，肝がん治療に有効とされる分子標的薬ラパマイシンの標的シグナルp70S6キナーゼが，NASH肝がんの病態に関与している可能性について検討した。 【方法】根治的外科手術療法を施行したNASH肝がん22例の病変組織に対して，リン酸化型（活性型）p70S6キナーゼの免疫組織化学染色を行い，臨床因子・予後の比較検討を行った。 【結果】NASH肝がん22例中12例（54.5%）がリン酸化型p70S6キナーゼを高発現しており，組織未分化度と相関した（p = 0.047）。リン酸化型P70S6キナーゼ高発現群は，外科切除後３年以内再発率が有意に増加していた（p = 0.045）。 【総括】p70S6キナーゼを高発現しているNASH肝がんは，再発頻度が高い傾向がある。同シグナルを阻害する分子標的薬ラパマイシンは，本疾患の再発防止に有効である可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Objective: Non-alcoholic steatohepatitis（NASH）is a recently identified liver disease which causes hepatocellular carcinoma（HCC）. In this study, we addressed whether p70S6 kinase（p70S6K）, a main target of the anti-cancer agent rapamycin, is involved in the clinicopathological factors in NASH-related HCC. Methods: HCC tissue samples were obtained from 22　NASH patients with radical surgical treatment. Phosphorylation level of p70S6K was analyzed by immunohistochemical analysis, and the correlation with the clinicopathological factors were examined. Results: Phosphorylated p70S6K was detected in 54.5%（12/22）of NASH-related HCCs. The levels of phosphop70S6K were correlated with histological grade of HCC（p = 0.047）, but not with clinical factors. Phosphorylation of p70S6K was correlated with increased cancer recurrence after 3 years of the treatment（p= 0.045）. Conclusion: Phosphorylation level of p70S6K was correlated with cancer recurrence of NASH-related HCC. Rapamycin might be a useful agent for treating NASH-associated HCC.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"164518","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Matsuda, Yasunobu"}]},{"nameIdentifiers":[{"nameIdentifier":"164519","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Wakai, Toshifumi"}]},{"nameIdentifiers":[{"nameIdentifier":"164520","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hirose, Yuki"}]},{"nameIdentifiers":[{"nameIdentifier":"164521","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sakata, Jun"}]},{"nameIdentifiers":[{"nameIdentifier":"164522","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kobayashi, Takashi"}]},{"nameIdentifiers":[{"nameIdentifier":"164523","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Osawa, Mami"}]},{"nameIdentifiers":[{"nameIdentifier":"164524","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fujimaki, Shun"}]},{"nameIdentifiers":[{"nameIdentifier":"164525","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kubota, Masayuki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学医学部保健学科"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12680484","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21884617","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松田, 康伸"}],"nameIdentifiers":[{"nameIdentifier":"164510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若井, 俊文"}],"nameIdentifiers":[{"nameIdentifier":"164511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣瀬, 雄己"}],"nameIdentifiers":[{"nameIdentifier":"164512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂田, 純"}],"nameIdentifiers":[{"nameIdentifier":"164513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 隆"}],"nameIdentifiers":[{"nameIdentifier":"164514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大澤, まみ"}],"nameIdentifiers":[{"nameIdentifier":"164515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤巻, 隼"}],"nameIdentifiers":[{"nameIdentifier":"164516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"窪田, 正幸"}],"nameIdentifiers":[{"nameIdentifier":"164517","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-20"}],"displaytype":"detail","filename":"11(1)_51-56.pdf","filesize":[{"value":"938.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"11(1)_51-56.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/28577/files/11(1)_51-56.pdf"},"version_id":"f9cd79a2-851b-454b-80f3-bcc8acdce878"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"非アルコール性脂肪肝炎","subitem_subject_scheme":"Other"},{"subitem_subject":"肝がん","subitem_subject_scheme":"Other"},{"subitem_subject":"p70S6キナーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"non-alcoholic steatohepatitis","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocellular carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"p70S6 kinase","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"非アルコール性脂肪肝炎関連肝細胞がんにおける活性型p70S6キナーゼの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"非アルコール性脂肪肝炎関連肝細胞がんにおける活性型p70S6キナーゼの解析"},{"subitem_title":"非アルコール性脂肪肝炎関連肝細胞がんにおける活性型p70S6キナーゼの解析","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1630"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-29"},"publish_date":"2016-02-29","publish_status":"0","recid":"28577","relation_version_is_last":true,"title":["非アルコール性脂肪肝炎関連肝細胞がんにおける活性型p70S6キナーゼの解析"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:58:46.179498+00:00"}