{"_buckets": {"deposit": "48c9f8a3-4843-4d31-9d01-0f085b9b4c73"}, "_deposit": {"id": "28395", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28395"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00028395"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u30e9\u30c3\u30c8\u597d\u5869\u57fa\u7403\u69d8RBL-2H3\u7d30\u80de\u306b\u304a\u3051\u308b\u03b3- \u30a2\u30df\u30ce\u916a\u9178\uff08GABA\uff09\u306e\u30d2\u30b9\u30bf\u30df\u30f3\u904a\u96e2\u6291\u5236\u4f5c\u7528"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "51", "bibliographicPageStart": "47", "bibliographicVolumeNumber": "61", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a"}, {"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Basophils and mast cells play a crucial role in immediate allergic reactions. These cells release various infl ammatory mediators including histamine in response to binding of antigen to its specifi c IgE bound to the high affi nity IgE receptor on the cell surface. In the present study, we examined the influence of \u03b3-aminobutyric acid (GABA) on histamine release in rat basophilic leukemia RBL-2H3 cells. After sensitization with anti-dinitrophenyl (DNP) IgE, challenge of RBL-2H3 cells with DNP-conjugated bovine serum albumin (DNP-BSA) caused a release of histamine in the cell suspension. The IgEmediated histamine release was suppressed by GABA, with about 60% inhibition at 100 \u03bcM. In the same condition, baclofen, a GABA_B receptor agonist, also inhibited histamine release. At a concentration of 100\u03bcM, the inhibition rate of baclofen was approximate 80% of histamine release induced by DNP-BSA stimulation. In addition, these inhibitory eff ects of GABA and baclofen were attenuated by the addition of CGP35348, a GABA_B receptor antagonist. These results suggest that GABA suppresses degranulation in basophils and mast cells via GABA_B receptor.", "subitem_description_type": "Abstract"}, {"subitem_description": "\u597d\u5869\u57fa\u7403\u3084\u30de\u30b9\u30c8\u7d30\u80de\u306f\u3001\u5373\u6642\u578b\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3046\u3002\u3053\u308c\u3089\u306e\u7d30\u80de\u306f\u3001\u7d30\u80de\u8868\u9762\u4e0a\u306e\u9ad8\u89aa\u548c\u6027IgE\u30ec\u30bb\u30d7\u30bf\u30fc\u306b\u7d50\u5408\u3057\u305f\u7279\u7570\u7684IgE 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"filename": "61(1)_47-51.pdf", "filesize": [{"value": "205.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 205300.0, "url": {"label": "61(1)_47-51.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/28395/files/61(1)_47-51.pdf"}, "version_id": "b5f5c22a-97c8-4479-b242-e01132c4e981"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "degranulation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u03b3-aminobutyric acid (GABA)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GABAB receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "histamine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "RBL-2H3 cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8131\u9846\u7c92", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u03b3- \u30a2\u30df\u30ce\u916a\u9178\uff08GABA\uff09", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GABA_B\u30ec\u30bb\u30d7\u30bf\u30fc", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30d2\u30b9\u30bf\u30df\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "RBL-2H3\u7d30\u80de", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Suppressive Effect of \u03b3-Aminobutyric Acid (GABA) on Histamine Release in Rat Basophilic RBL-2H3 Cells", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Suppressive Effect of \u03b3-Aminobutyric Acid (GABA) on Histamine Release in Rat Basophilic RBL-2H3 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