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  1. 260 大学院医歯学総合研究科(歯)
  2. 10 学術雑誌論文
  3. 10 査読済論文
  1. 0 資料タイプ別
  2. 01 学術雑誌論文

Immunocytochemical Localization of MAPKAPK-2 and Hsp25 in the Rat Temporomandibular Joint

http://hdl.handle.net/10191/1806
http://hdl.handle.net/10191/1806
d9ef8222-7381-4c8a-829d-1b3705e56263
名前 / ファイル ライセンス アクション
9_0009.pdf 9_0009.pdf (107.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-05-10
タイトル
タイトル Immunocytochemical Localization of MAPKAPK-2 and Hsp25 in the Rat Temporomandibular Joint
タイトル
言語 en
タイトル Immunocytochemical Localization of MAPKAPK-2 and Hsp25 in the Rat Temporomandibular Joint
言語
言語 eng
キーワード
主題Scheme Other
主題 temporomandibular joint
キーワード
主題Scheme Other
主題 synovial membrane
キーワード
主題Scheme Other
主題 synovial lining cell
キーワード
主題Scheme Other
主題 MAPKAPK-2
キーワード
主題Scheme Other
主題 Hsp25
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Nozawa-Inoue, Kayoko

× Nozawa-Inoue, Kayoko

WEKO 38118

Nozawa-Inoue, Kayoko

Search repository
Amizuka, Norio

× Amizuka, Norio

WEKO 38119

Amizuka, Norio

Search repository
Suzuki, Akiko

× Suzuki, Akiko

WEKO 38120

Suzuki, Akiko

Search repository
Maeda, Takeyasu

× Maeda, Takeyasu

WEKO 38121

Maeda, Takeyasu

Search repository
著者別名
識別子 38122
識別子Scheme WEKO
姓名 野澤-井上, 佳世子
抄録
内容記述タイプ Abstract
内容記述 One series of our research has shown an intense expression of immunoreaction for heat shock protein 25 (Hsp25) in various cellular elements in the rat temporomandibular joint (TMJ). This protein is the major substrate of mitogen-activated protein kinase-activated protein kinase-2 (MAPKAPK-2), which mediates an intracellular stress-activated signaling pathway to stimulate cytosolic actin reorganization under various stresses. The present study was undertaken to examine the localization of MAPKAPK-2 in the rat TMJ by immunocytochemical techniques. Furthermore, confocal microscopy with double staining was employed to demonstrate the co-localization of MAPKAPK-2 and Hsp25. Immunocytochemistry for MAPKAPK-2 showed an intense immunoreaction in the cytoplasm of the synovial lining cells, the endothelial cells, and the fibroblasts in the synovial membrane of the rat TMJ. Double immunostaining under a confocal microscope succeeded in demonstrating the co-localization of MAPKAPK-2- and Hsp25-immunoreactions in the cytoplasm of fibroblastic type B synoviocytes in the TMJ. On the other hand, the macrophage-like type A cells expressed MAPKAPK-2-immunoreactions but lacked Hsp25-immunoreactivity. The cells in the articular disc and the chondrocytes in the maturative and hypertrophic layer of the mandibular cartilage also showed intense immunoreactions for MAPKAPK-2 and Hsp25. In addition to cytoplasmic localization, MAPKAPK-2- immunoreactions were found in the nucleus of some synovial lining cells, cells in the articular disc, and chondrocytes. Current observations imply that the presence of the phosphorylation of Hsp25 via activated MAPKAPK-2 in the cytoplasm. The MAPKAPK-2 and Hsp25 possibly participate in the induction of cytoskeletal changes to the various cellular elements in rat TMJ under normal conditions.
書誌情報 The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology
en : The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology

巻 284A, 号 2, p. 522-528, 発行日 2005-06
出版者
出版者 John Wiley & Sons Ltd.
ISSN
収録物識別子タイプ ISSN
収録物識別子 15524884
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11814687
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1002/ar.a.20191
権利
権利情報 Wiley-Liss, Inc.
著者版フラグ
値 author
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