{"_buckets": {"deposit": "4d4b64c9-83a6-4c0e-a62f-8ec955eb6ed1"}, "_deposit": {"id": "26047", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "26047"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00026047"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Localization of Interleukin-1 (IL-1) mRNA-expressing macrophages in human inflamed gingiva and IL-1 activity in gingival crevicular fluid"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "64", "bibliographicPageStart": "53", "bibliographicVolumeNumber": "21", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u6b6f\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u6b6f\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The purpose of this study was to determine the exact cell type and site(s) involved in interleukin-1 (IL-1) production during gingival inflammation. By combining immunohistochemistry and in situ hybridization, IL-1messenger RNA (mRNA) \u2013expressing cells in human inflamed gingival were identified as macrophages. The rate of IL-1\u03b1 mRNA expression in these macrophages was the same as IL-1\u03b2mRNA expression. Additionally, the rate of IL-1 mRNA expression was higher in tissue sections furthest from sulcular areas than in those closest of sulcular lesions, although more macrophages were present at the sulcular site. The IL-1 activity in gingival crevicular fluid (GCF) obtained from inframed gingival was higher than that from healthy gingival and decreased after periodontal therapy. The IL-1 activity in GCF was almost completely abolished by the addition of anti-IL-1\u03b1 antibody but not anti-IL-1\u03b2antibody, indicating that IL-1\u03b1 is the predominant form in GCF. However, the IL-1 activity in GCF was unrelated to the number of IL-1 mRNA-expressing macrophages in the same gingival site where the GCF was obtained at the same time. The results suggest that macrophages in the oral side contribute to the production of IL-1 but those in the sulcular side play a different role in the generation of gingival inflammation.", "subitem_description_type": "Abstract"}, {"subitem_description": "\u6b6f\u5468\u708e\u7f79\u60a3\u8005\u306e\u6b6f\u8089\u7d44\u7e54\u4e2d\u306b\u304a\u3051\u308b\u30a4\u30f3\u30bf\u30fc\u30ea\u30e5\u30a6\u30ad\u30f31 (IL-1) mRNA\u767a\u73fe\u7d30\u80de\u306e\u5c40\u5728\u53ca\u3073\u6b6f\u8089\u6e9d\u6ef2\u51fa\u6db2 (GCF) 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