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We hence measured IL-1\u03b1, IL-1\u03b2 and osteocalcin levels in gingival crevicular fluid (GCF) of patients with periodontitis and patients in maintenance phase. IL-1\u03b1 in GCF of periodontitis patients was strikingly higher than in GCF of maintenance patients, whereas IL-1\u03b2 levels only slightly differed between the two groups. IL-1\u03b1 and \u03b2 levels in GCF of young orthodontic patients increased at 2 days after setting of orthodontic appliance, then recovered the pre-orthodontic levels at 2 weeks. No change in osteocalcin level was observed. These imply that the orthodontic force changed the metabolism of periodontal tissues including alveolar bone for only a short time span, which shows that the orthodontic force was adequate. In middle-aged periodontitis patients, IL-1\u03b1, L-1\u03b2 and osteocalcin levels did not change. Therefore, orthodontic force did not affect the periodontal tissue metabolism, demonstrating the adequacy of the orthodontic therapy.", "subitem_description_type": "Abstract"}, {"subitem_description": 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