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  1. 260 大学院医歯学総合研究科(歯)
  2. 20 紀要
  3. 01 新潟歯学会雑誌
  4. 第24巻第2号
  1. 0 資料タイプ別
  2. 03 紀要論文

Effects of Protein Kinase C on the L-Type Ca2+ Channel in Single Rabbit Sino-Atrial Nodal Cells : Analysis by Patch-Clamp Technique

http://hdl.handle.net/10191/22904
http://hdl.handle.net/10191/22904
2bbe75cd-1ffe-4dec-b85d-8d1a482a160a
名前 / ファイル ライセンス アクション
NS_24(2)_21-28.pdf NS_24(2)_21-28.pdf (632.9 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-08-07
タイトル
タイトル Effects of Protein Kinase C on the L-Type Ca2+ Channel in Single Rabbit Sino-Atrial Nodal Cells : Analysis by Patch-Clamp Technique
タイトル
言語 en
タイトル Effects of Protein Kinase C on the L-Type Ca2+ Channel in Single Rabbit Sino-Atrial Nodal Cells : Analysis by Patch-Clamp Technique
言語
言語 eng
キーワード
主題Scheme Other
主題 Protein Kinase C
キーワード
主題Scheme Other
主題 H-7
キーワード
主題Scheme Other
主題 Whole-cell clamp
キーワード
主題Scheme Other
主題 Cell-attached patch clamp
キーワード
主題Scheme Other
主題 Single sino-atrial nodal cell
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル プロテインキナーゼCの単一ウサギ洞房結節細胞L型Ca2 チャネルに対する作用:ホールセルとセルアタッチ・パッチクランプ法による解析
著者 Satoh, Hiroyasu

× Satoh, Hiroyasu

WEKO 153318

Satoh, Hiroyasu

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著者別名
識別子 153319
識別子Scheme WEKO
姓名 佐藤, 広康
抄録
内容記述タイプ Abstract
内容記述 Efects of phorbol esters (stimulator of protein kinase C) on the L-type Ca^2+ current in isolated single rabbit sino-atrial (SA) nodal cells were examined. In whole-cell voltage-clamp experiments, 12-0-tetradecanoylphorbo1-13-acetate (TPA) at 10^-7 M inhibited the L-type Ca^2+ current. Pretreatment with H-7 (10^-5 M), an antagonist of protein kinase C (PK-C), did not modify the TPA-induced depression. The time course of inactivation process for the L-type Ca^2 current was slowed. In cell-attached patch-clamp experiments, TPA (10^-7 M) profoundly decreased the probability of the opening of unitary L-type Ca^2+ channels (a dihydropyridine-sensitive). The conductance was unaffected (18 ± 1pS, n=5). Even H-7(10^-5 M) alone tended to inhibit the opening of the channels. Addition of TPA (10^-7 M) to the H-7-containing solution caused further decrease in the opening. On the other hand, 4-alpha-phorbol-12, 13-didecanoate (not a PK-C activator) had no effect on the Ca^2+ channels. These results indicate that the PK-C Stimulation decreases the opening of L-type Ca^2+ channels of the SA nodal cell membranes.
書誌情報 新潟歯学会雑誌
en : 新潟歯学会雑誌

巻 24, 号 2, p. 21-28, 発行日 1994-12
出版者
出版者 新潟歯学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 03850153
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN0018300X
著者版フラグ
値 publisher
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