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Effects of Protein Kinase C on the L-Type Ca2+ Channel in Single Rabbit Sino-Atrial Nodal Cells : Analysis by Patch-Clamp Technique
http://hdl.handle.net/10191/22904
http://hdl.handle.net/10191/229042bbe75cd-1ffe-4dec-b85d-8d1a482a160a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
NS_24(2)_21-28.pdf (632.9 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-08-07 | |||||
| タイトル | ||||||
| タイトル | Effects of Protein Kinase C on the L-Type Ca2+ Channel in Single Rabbit Sino-Atrial Nodal Cells : Analysis by Patch-Clamp Technique | |||||
| タイトル | ||||||
| タイトル | Effects of Protein Kinase C on the L-Type Ca2+ Channel in Single Rabbit Sino-Atrial Nodal Cells : Analysis by Patch-Clamp Technique | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Protein Kinase C | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | H-7 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Whole-cell clamp | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cell-attached patch clamp | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Single sino-atrial nodal cell | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | プロテインキナーゼＣの単一ウサギ洞房結節細胞Ｌ型Ｃａ2 チャネルに対する作用：ホールセルとセルアタッチ・パッチクランプ法による解析 | |||||
| 著者 |
Satoh, Hiroyasu
× Satoh, Hiroyasu |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 153319 | |||||
| 姓名 | 佐藤, 広康 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Efects of phorbol esters (stimulator of protein kinase C) on the L-type Ca^2+ current in isolated single rabbit sino-atrial (SA) nodal cells were examined. In whole-cell voltage-clamp experiments, 12-0-tetradecanoylphorbo1-13-acetate (TPA) at 10^-7 M inhibited the L-type Ca^2+ current. Pretreatment with H-7 (10^-5 M), an antagonist of protein kinase C (PK-C), did not modify the TPA-induced depression. The time course of inactivation process for the L-type Ca^2 current was slowed. In cell-attached patch-clamp experiments, TPA (10^-7 M) profoundly decreased the probability of the opening of unitary L-type Ca^2+ channels (a dihydropyridine-sensitive). The conductance was unaffected (18 ± 1pS, n=5). Even H-7(10^-5 M) alone tended to inhibit the opening of the channels. Addition of TPA (10^-7 M) to the H-7-containing solution caused further decrease in the opening. On the other hand, 4-alpha-phorbol-12, 13-didecanoate (not a PK-C activator) had no effect on the Ca^2+ channels. These results indicate that the PK-C Stimulation decreases the opening of L-type Ca^2+ channels of the SA nodal cell membranes. | |||||
| 書誌情報 |
新潟歯学会雑誌 en : 新潟歯学会雑誌 巻 24, 号 2, p. 21-28, 発行日 1994-12 |
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| 出版者 | ||||||
| 出版者 | 新潟歯学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03850153 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0018300X | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Satoh, Hiroyasu, 1994, Effects of Protein Kinase C on the L-Type Ca2+ Channel in Single Rabbit Sino-Atrial Nodal Cells : Analysis by Patch-Clamp Technique: 新潟歯学会, 21–28 p.
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