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Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland
http://hdl.handle.net/10191/23241
http://hdl.handle.net/10191/232419c2e0f44-f755-452b-9ea7-d2500b035920
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
NS_32(2)_17-26.pdf (5.5 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2013-08-27 | |||||
| タイトル | ||||||
| タイトル | Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland | |||||
| タイトル | ||||||
| タイトル | Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | superoxide dismutase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | submandibular gland | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | development | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rat | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Arimatsu, Mikiko
× Arimatsu, Mikiko× Maeda, Takeyasu× Kawano, Yoshiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Manganase- and copper-zinc superoxide dismutases (Mn- and Cu/Zn-SODs) are representative enzymes for scavenging superoxide radicals, which are considered to cause aging and cell damage. Our recent study has demonstrated the localization of Mn-and Cu/Zn-SOD proteins as well as the expression of Mn-and Cu/Zn-SOD mRNAs in all types of duct cells-and not in acinar cells- in the submandibular gland of adult rats. However, the expression of these two enzymes remains unclear in rat developing submandibular gland. Thus, the present study examined the expression of Mn- and Cu/Zn-SODs in the submandibular gland of rats aged from embryonic 18 days to postnatal 8 weeks by an immunohistochemical technique using specific antisera. The deparaffinized sections were processed for the avidin-biotin complex method. On the prenatal 18th day, a small number of epithelial duct cells and cells in acini exhibited Cu/Zn-SOD-immunoreactivity, but they did not show any immunoreactions for Mn-SODs. From postnatal 1day to 1 week, Mn- and Cu/Zn-SOD-immunoreactivities were found in both the duct cells and the cells in acini. This drastic change in the expression of Mn- and Cu/Zn-SOD-immunoreactivities between prenatal and postnatal periods was believed to relate to the commencement of pulmonary respiration due to oxygen exposure. After 2 weeks, however, the cells in the acini lost Mn- and Cu/Zn-SOD-immunoreactions, though the duct cells retained them, suggesting that the duct cells in the mature submandibular gland exhibit greater resistance against oxidative stress than do the acinar cells. | |||||
| 書誌情報 |
新潟歯学会雑誌 en : 新潟歯学会雑誌 巻 32, 号 2, p. 17-26, 発行日 2002-12 |
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| 出版者 | ||||||
| 出版者 | 新潟歯学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03850153 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN0018300X | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
