{"created":"2021-03-01T06:31:11.424469+00:00","id":25689,"links":{},"metadata":{"_buckets":{"deposit":"5976673a-4520-4887-9a8b-f77e949b4558"},"_deposit":{"id":"25689","owners":[],"pid":{"revision_id":0,"type":"depid","value":"25689"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00025689","sets":["432:1291:1292:1313","453:456"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"26","bibliographicPageStart":"17","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"新潟歯学会雑誌"},{"bibliographic_title":"新潟歯学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Manganase- and copper-zinc superoxide dismutases (Mn- and Cu/Zn-SODs) are representative enzymes for scavenging superoxide radicals, which are considered to cause aging and cell damage. Our recent study has demonstrated the localization of Mn-and Cu/Zn-SOD proteins as well as the expression of Mn-and Cu/Zn-SOD mRNAs in all types of duct cells-and not in acinar cells- in the submandibular gland of adult rats. However, the expression of these two enzymes remains unclear in rat developing submandibular gland. Thus, the present study examined the expression of Mn- and Cu/Zn-SODs in the submandibular gland of rats aged from embryonic 18 days to postnatal 8 weeks by an immunohistochemical technique using specific antisera. The deparaffinized sections were processed for the avidin-biotin complex method. On the prenatal 18th day, a small number of epithelial duct cells and cells in acini exhibited Cu/Zn-SOD-immunoreactivity, but they did not show any immunoreactions for Mn-SODs. From postnatal 1day to 1 week, Mn- and Cu/Zn-SOD-immunoreactivities were found in both the duct cells and the cells in acini. This drastic change in the expression of Mn- and Cu/Zn-SOD-immunoreactivities between prenatal and postnatal periods was believed to relate to the commencement of pulmonary respiration due to oxygen exposure. After 2 weeks, however, the cells in the acini lost Mn- and Cu/Zn-SOD-immunoreactions, though the duct cells retained them, suggesting that the duct cells in the mature submandibular gland exhibit greater resistance against oxidative stress than do the acinar cells.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟歯学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN0018300X","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03850153","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Arimatsu, Mikiko"}],"nameIdentifiers":[{"nameIdentifier":"151453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Takeyasu"}],"nameIdentifiers":[{"nameIdentifier":"151454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawano, Yoshiro"}],"nameIdentifiers":[{"nameIdentifier":"151455","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"NS_32(2)_17-26.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"NS_32(2)_17-26.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/25689/files/NS_32(2)_17-26.pdf"},"version_id":"ce8a0442-0a8b-4a93-abfc-9e9f32e895d8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"superoxide dismutase","subitem_subject_scheme":"Other"},{"subitem_subject":"submandibular gland","subitem_subject_scheme":"Other"},{"subitem_subject":"development","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland"},{"subitem_title":"Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1313"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"25689","relation_version_is_last":true,"title":["Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:55:42.081406+00:00"}