{"created":"2021-03-01T06:31:11.424469+00:00","id":25689,"links":{},"metadata":{"_buckets":{"deposit":"5976673a-4520-4887-9a8b-f77e949b4558"},"_deposit":{"id":"25689","owners":[],"pid":{"revision_id":0,"type":"depid","value":"25689"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00025689"},"item_7_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"26","bibliographicPageStart":"17","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"\u65b0\u6f5f\u6b6f\u5b66\u4f1a\u96d1\u8a8c"},{"bibliographic_title":"\u65b0\u6f5f\u6b6f\u5b66\u4f1a\u96d1\u8a8c","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"Manganase- and copper-zinc superoxide dismutases (Mn- and Cu/Zn-SODs) are representative enzymes for scavenging superoxide radicals, which are considered to cause aging and cell damage. Our recent study has demonstrated the localization of Mn-and Cu/Zn-SOD proteins as well as the expression of Mn-and Cu/Zn-SOD mRNAs in all types of duct cells-and not in acinar cells- in the submandibular gland of adult rats. However, the expression of these two enzymes remains unclear in rat developing submandibular gland. Thus, the present study examined the expression of Mn- and Cu/Zn-SODs in the submandibular gland of rats aged from embryonic 18 days to postnatal 8 weeks by an immunohistochemical technique using specific antisera. The deparaffinized sections were processed for the avidin-biotin complex method. On the prenatal 18th day, a small number of epithelial duct cells and cells in acini exhibited Cu/Zn-SOD-immunoreactivity, but they did not show any immunoreactions for Mn-SODs. From postnatal 1day to 1 week, Mn- and Cu/Zn-SOD-immunoreactivities were found in both the duct cells and the cells in acini. This drastic change in the expression of Mn- and Cu/Zn-SOD-immunoreactivities between prenatal and postnatal periods was believed to relate to the commencement of pulmonary respiration due to oxygen exposure. After 2 weeks, however, the cells in the acini lost Mn- and Cu/Zn-SOD-immunoreactions, though the duct cells retained them, suggesting that the duct cells in the mature submandibular gland exhibit greater resistance against oxidative stress than do the acinar cells.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"\u65b0\u6f5f\u6b6f\u5b66\u4f1a"}]},"item_7_select_19":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0018300X","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03850153","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Arimatsu, Mikiko"}],"nameIdentifiers":[{"nameIdentifier":"151453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Takeyasu"}],"nameIdentifiers":[{"nameIdentifier":"151454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawano, Yoshiro"}],"nameIdentifiers":[{"nameIdentifier":"151455","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"NS_32(2)_17-26.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"NS_32(2)_17-26.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/25689/files/NS_32(2)_17-26.pdf"},"version_id":"ce8a0442-0a8b-4a93-abfc-9e9f32e895d8"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"superoxide dismutase","subitem_subject_scheme":"Other"},{"subitem_subject":"submandibular gland","subitem_subject_scheme":"Other"},{"subitem_subject":"development","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland"},{"subitem_title":"Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["453/456","432/1291/1292/1313"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"25689","relation_version_is_last":true,"title":["Expression of Immunoreactivities for Manganese and Copper/Zinc Superoxide Dismutases(Mn-and Cu/Zn-SODs)During Development of the Rat Submandibular Gland"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T12:03:25.453836+00:00"}