{"_buckets": {"deposit": "39b7c8fc-6f47-4b50-a10c-6e832f58caf0"}, "_deposit": {"id": "25601", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "25601"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00025601"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Candidate gene analysis at F13A1, D16S539, and BCL3 loci regarding to non-syndromic cleft lip with or wihout cleft palate in Japanese families"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "18", "bibliographicPageStart": "11", "bibliographicVolumeNumber": "35", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u6b6f\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u6b6f\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We have examined about the relationship between cleft lip with or without cleft palate and three genetic loci of F13A1\uff086p25.3\uff0dp24.3\uff09,D16S539(16q24\uff09and BCL3\uff0819q13.2\uff09. At first, we extracted genome DNA frorn the 77 patients and their parents that were obtained written and oral informed consent. Secondly, we amplified each DNA using the microsatellite marker of genetic loci. Then we detected alleles by 8\uff05 polyacrylamide gel electrophoresis. Finally, we performed a transmission disequilibrium test \uff08TDT\uff09 and an association test. The results of the TDT were P=0.995\uff08XX\uff1d0.067\uff09 at F13A1, 0.167\uff08XX=9.124) at D16S539 and 0.679\uff08XX=1.512\uff09 at BCL3. The empirical P values of three genetic loci were 0.379, 0.798 and 0.828, respectively. We could not find a statistical significance either in each locus or any specific allele, so transmission disequilibrium was not approved. However, the P value in D16S539 was comparatively low, and we got comparatively high empirical P values in D16S539 and BCL3. The results of the association test were P\uff1d0.062\uff08XX\uff1d7.33\uff09 at F13A1,0.088 (XX=10.99\uff09 at D16S539 and 0.061 (XX=7.36\uff09 at BCL3. The P values were approximate to statistical significance although we could not find a significant difference between patients and control subjects. These lines of evidence do not suggest a significant result, but are not the results that denied actively F13A1, D16S539 and BCL3 as candidate genes. We need to accumulate the case and analysis further more in the future.", "subitem_description_type": "Abstract"}, {"subitem_description": "\u5507\u88c2\u30fb\u5507\u984e\u53e3\u84cb\u88c2\uff08CL\uff0fP\uff09\u306b\u304a\u3051\u308bF13A1\uff086p25.3\u30fbp24.3\uff09\u3001D16S539\uff0816q24\uff09\u3001BCL3\uff0819q13.2\uff09\u306e3\u3064\u306e\u907a\u4f1d\u5b50\u5ea7\u3068\u672c\u75be\u60a3\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u691c\u8a0e\u3092\u884c\u3063\u305f\u3002\u30a4\u30f3\u30d5\u30a9\u30fc\u30e0\u30c9\u30b3\u30f3\u30bb\u30f3\u30c8\u306e\u5f97\u3089\u308c\u305fCL\uff0fP 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