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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第100巻第4号

成人T細胞白血病・リンパ腫患者ならびにヒトT細胞指向性ウイルスI 型感染健常人の免疫機能

http://hdl.handle.net/10191/34820
http://hdl.handle.net/10191/34820
27a1a328-75d3-496b-bb54-aedd4ca91d2b
名前 / ファイル ライセンス アクション
100(4)_212-224.pdf 100(4)_212-224.pdf (1.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-12-03
タイトル
タイトル 成人T細胞白血病・リンパ腫患者ならびにヒトT細胞指向性ウイルスI 型感染健常人の免疫機能
タイトル
言語 en
タイトル 成人T細胞白血病・リンパ腫患者ならびにヒトT細胞指向性ウイルスI 型感染健常人の免疫機能
言語
言語 jpn
キーワード
主題Scheme Other
主題 adult T-cell leukemia/lymphoma
キーワード
主題Scheme Other
主題 human T-lymphotropic retrovirus type I
キーワード
主題Scheme Other
主題 antibody-dependent cell-mediated cytotoxicity
キーワード
主題Scheme Other
主題 complement-dependent cytotoxicity
キーワード
主題Scheme Other
主題 peripheral blood mononuclear cells
キーワード
主題Scheme Other
主題 成人 T 細胞白血病・リンパ腫
キーワード
主題Scheme Other
主題 ヒト T 細胞指向性ウイルス I 型
キーワード
主題Scheme Other
主題 抗体依存性細胞性細胞障害
キーワード
主題Scheme Other
主題 補体依存性細胞障害
キーワード
主題Scheme Other
主題 末梢血単核細胞
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Immunological Function in Patients with Adult T-Cell Leukemia/Lymphoma and in Healthy Persons Infected with Human T-Lymphotropic Retrovirus Type I
著者 宮腰, 秀夫

× 宮腰, 秀夫

WEKO 147717

宮腰, 秀夫

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著者別名
識別子 147718
識別子Scheme WEKO
姓名 Miyakoshi, Hideo
抄録
内容記述タイプ Abstract
内容記述 Immunological functions of peripheral blood mononuclear cells (PBMC) Were examined in patients with adult T-cell leukemia/lymphoma (ATL) and in healthy persons who were positive for antibody (seropositive) to human T-lymphotropic retrovirus type I (HTLV-I). The lowered immunoreactivity of PBMC was observed in ATL patients when the mitogen-induced lymphoproliferation and the natural killer cell activity were used as the nonspecific immunological parameter. In contrast, PBMC from seropositive healthy persons possessed normal reactivity except for the staphage lysate-induced lymphoproliferation. The spontaneous DNA synthesis of PBMC was extremely high in both ATL patients and seropositive healthy persons. HTLV-I-producing cells were lysed by the PBMC from seropositive and seronegative healthy persons in the presence of natural antibodies to HTLV-I-related antigens (antibody-dependent cell-mediated cytotoxicity, ADCC). Effector cells of ADCC were Leu 7^+ K cells. However, no cytotoxicity was caused by PBMC from ATL patients even in the presence of antibody. As an antibody source, plasmas from ATL patients as well as seropositive healthy persons were effective in not only ADCC but also complement-dependent cytotoxicity against HTLV-I-producing cells when supplemented with rabbit serum as a complement source. According to these results, it is plausible to consider that the depression of immunological functions, especially cell-mediated immunoreactivity, is correlated with the HTLV-I-induced malignancy.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 100, 号 4, p. 212-224, 発行日 1986-04
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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