@article{oai:niigata-u.repo.nii.ac.jp:00024785,
 author = {宮腰, 秀夫},
 issue = {4},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Apr},
 note = {Immunological functions of peripheral blood mononuclear cells (PBMC) Were examined in patients with adult T-cell leukemia/lymphoma (ATL) and in healthy persons who were positive for antibody (seropositive) to human T-lymphotropic retrovirus type I (HTLV-I). The lowered immunoreactivity of PBMC was observed in ATL patients when the mitogen-induced lymphoproliferation and the natural killer cell activity were used as the nonspecific immunological parameter. In contrast, PBMC from seropositive healthy persons possessed normal reactivity except for the staphage lysate-induced lymphoproliferation. The spontaneous DNA synthesis of PBMC was extremely high in both ATL patients and seropositive healthy persons. HTLV-I-producing cells were lysed by the PBMC from seropositive and seronegative healthy persons in  the presence of natural antibodies to HTLV-I-related antigens (antibody-dependent cell-mediated cytotoxicity, ADCC). Effector cells of ADCC were Leu 7^+ K cells.  However, no cytotoxicity was caused by PBMC from ATL patients even in the presence of antibody.  As an antibody source, plasmas from ATL patients as well as seropositive healthy persons were effective in not only ADCC but also complement-dependent cytotoxicity against HTLV-I-producing cells when supplemented with rabbit serum as a complement source. According to these results, it is plausible to consider that the depression of immunological functions, especially cell-mediated immunoreactivity, is correlated with the HTLV-I-induced malignancy.},
 pages = {212--224},
 title = {成人T細胞白血病･リンパ腫患者ならびにヒトT細胞指向性ウイルスI 型感染健常人の免疫機能},
 volume = {100},
 year = {1986}
}