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Activation of protein C by thrombin is markedly enhanced by the thrombomodulin in the endothelial cell. Activated protein C exerts an anticoagulant by inhibiting F. Va and F. VIIIa selectively. Protein C levels were measured by the amidolytic activity of the activated protein C against the chromogenic substrate (S-2266) in the patients with the cerebrovascular diseases, the patients with liver cirrhosis, and the patients receiving warfarin therapy. Protein C levels in the patients with cerebrovascular diseases were normal, whereas its ievels in the patients with liver cirrhosis and patients receiving warfarin therapy were significantly low, 33.2\u00b123% and 65\u00b121%, respectively.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "147223", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kazama, Yosiaki"}]}, {"nameIdentifiers": [{"nameIdentifier": "147224", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Niwa, Masahiro"}]}, {"nameIdentifiers": [{"nameIdentifier": "147225", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kondo, Shin-ich"}]}, {"nameIdentifiers": [{"nameIdentifier": "147226", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takahashi, Kaoru"}]}, {"nameIdentifiers": [{"nameIdentifier": "147227", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sakuragawa, 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