{"_buckets": {"deposit": "7ecad1f5-3f6f-4033-b7c4-5cb3b2e797bb"}, "_deposit": {"id": "24597", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "24597"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00024597", "sets": ["456", "1242"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Immunohistological Study of Epidermal Cells and Dermal Infiltrates in Lichenoid Drug Eruption (Present Status of Drug Allergy)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1986-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "500", "bibliographicPageStart": "497", "bibliographicVolumeNumber": "100", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In order to study an immunopathological mechanism in lichenoid drug eruption, an immunofluorescence and an immunoperoxidase techniques were performed using monoclonal antibodies on frozen tissue sections from 4 patients. OKT4-positive cells (helper/inducer T cells, DTH T cells) were major components of infiltrating cells in the dermis and were detected at the dermo-epidermal junction (D-E junction). OKT8-positive cells (suppressor/killer T cells) could also be identified in the epidermis and D-E junction. Increased numbers of OKT6-positive cells (Langerhans cells) were seen in the epidermis and dermis, OKIa1, a monoclonal antibody reactive with human HLA-DR antigens, showed positive labelling of keratinocytes and dermal infiltrates. Furthermore, there were some anti-IL-2 receptor-positive cells in the dermal infiltrates. These findings suggest that expression of HLA-DR antigens on the keratinocyte membrane and activation of autoreactive T cells may play a significant role in the etiopathogenesis of lichenoid drug eruption.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "146835", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yamaguchi, Shigemitsu"}]}, {"nameIdentifiers": [{"nameIdentifier": "146836", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Tanaka, masaaki"}]}, {"nameIdentifiers": [{"nameIdentifier": "146837", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Matsuzaki, Teruki"}]}, {"nameIdentifiers": [{"nameIdentifier": "146838", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sato, yoshio"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "山口, 茂光"}], "nameIdentifiers": [{"nameIdentifier": "146831", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "田中, 正明"}], "nameIdentifiers": [{"nameIdentifier": "146832", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "松崎, 照樹"}], "nameIdentifiers": [{"nameIdentifier": "146833", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐藤, 良夫"}], "nameIdentifiers": [{"nameIdentifier": "146834", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "100(9)_497-500.pdf", "filesize": [{"value": "344.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 344300.0, "url": {"label": "100(9)_497-500.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/24597/files/100(9)_497-500.pdf"}, "version_id": "49b591a7-aa1c-48e9-b7f4-bd0e102e286b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "lichenoid drug eruption", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immunoperoxidase technique", "subitem_subject_scheme": "Other"}, {"subitem_subject": "monoclonal antibody", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HLA-DR", "subitem_subject_scheme": "Other"}, {"subitem_subject": "autoreactive T cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "扇平苔癬型薬疹", "subitem_subject_scheme": "Other"}, {"subitem_subject": "酵素抗体法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "単クローン抗体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "自己反応性 T 細胞", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "2) 薬疹,特に扁平苔癬型薬疹における免疫組織学的検索(シンポジウム 「薬剤アレルギーの現状」, 第415回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "2) 薬疹,特に扁平苔癬型薬疹における免疫組織学的検索(シンポジウム 「薬剤アレルギーの現状」, 第415回新潟医学会)"}, {"subitem_title": "2) 薬疹,特に扁平苔癬型薬疹における免疫組織学的検索(シンポジウム 「薬剤アレルギーの現状」, 第415回新潟医学会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1242"], "permalink_uri": "http://hdl.handle.net/10191/35058", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-12-07"}, "publish_date": "2015-12-07", "publish_status": "0", "recid": "24597", "relation": {}, "relation_version_is_last": true, "title": ["2) 薬疹,特に扁平苔癬型薬疹における免疫組織学的検索(シンポジウム 「薬剤アレルギーの現状」, 第415回新潟医学会)"], "weko_shared_id": null}