{"created":"2021-03-01T06:29:58.671137+00:00","id":24597,"links":{},"metadata":{"_buckets":{"deposit":"7ecad1f5-3f6f-4033-b7c4-5cb3b2e797bb"},"_deposit":{"id":"24597","owners":[],"pid":{"revision_id":0,"type":"depid","value":"24597"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00024597","sets":["453:456","471:537:538:1242"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Immunohistological Study of Epidermal Cells and Dermal Infiltrates in Lichenoid Drug Eruption (Present Status of Drug Allergy)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"500","bibliographicPageStart":"497","bibliographicVolumeNumber":"100","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to study an immunopathological mechanism in lichenoid drug eruption, an immunofluorescence and an immunoperoxidase techniques were performed using monoclonal antibodies on frozen tissue sections from 4 patients. OKT4-positive cells (helper/inducer T cells, DTH T cells) were major components of infiltrating cells in the dermis and were detected at the dermo-epidermal junction (D-E junction). OKT8-positive cells (suppressor/killer T cells) could also be identified in the epidermis and D-E junction. Increased numbers of OKT6-positive cells (Langerhans cells) were seen in the epidermis and dermis, OKIa1, a monoclonal antibody reactive with human HLA-DR antigens, showed positive labelling of keratinocytes and dermal infiltrates. Furthermore, there were some anti-IL-2 receptor-positive cells in the dermal infiltrates. These findings suggest that expression of HLA-DR antigens on the keratinocyte membrane and activation of autoreactive T cells may play a significant role in the etiopathogenesis of lichenoid drug eruption.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"146835","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamaguchi, Shigemitsu"}]},{"nameIdentifiers":[{"nameIdentifier":"146836","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tanaka, masaaki"}]},{"nameIdentifiers":[{"nameIdentifier":"146837","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Matsuzaki, Teruki"}]},{"nameIdentifiers":[{"nameIdentifier":"146838","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sato, yoshio"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山口, 茂光"}],"nameIdentifiers":[{"nameIdentifier":"146831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 正明"}],"nameIdentifiers":[{"nameIdentifier":"146832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松崎, 照樹"}],"nameIdentifiers":[{"nameIdentifier":"146833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 良夫"}],"nameIdentifiers":[{"nameIdentifier":"146834","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"100(9)_497-500.pdf","filesize":[{"value":"344.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"100(9)_497-500.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/24597/files/100(9)_497-500.pdf"},"version_id":"49b591a7-aa1c-48e9-b7f4-bd0e102e286b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lichenoid drug eruption","subitem_subject_scheme":"Other"},{"subitem_subject":"immunoperoxidase technique","subitem_subject_scheme":"Other"},{"subitem_subject":"monoclonal antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA-DR","subitem_subject_scheme":"Other"},{"subitem_subject":"autoreactive T cell","subitem_subject_scheme":"Other"},{"subitem_subject":"扇平苔癬型薬疹","subitem_subject_scheme":"Other"},{"subitem_subject":"酵素抗体法","subitem_subject_scheme":"Other"},{"subitem_subject":"単クローン抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"自己反応性 T 細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2) 薬疹,特に扁平苔癬型薬疹における免疫組織学的検索(シンポジウム 「薬剤アレルギーの現状」, 第415回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2) 薬疹,特に扁平苔癬型薬疹における免疫組織学的検索(シンポジウム 「薬剤アレルギーの現状」, 第415回新潟医学会)"},{"subitem_title":"2) 薬疹,特に扁平苔癬型薬疹における免疫組織学的検索(シンポジウム 「薬剤アレルギーの現状」, 第415回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1242"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-07"},"publish_date":"2015-12-07","publish_status":"0","recid":"24597","relation_version_is_last":true,"title":["2) 薬疹,特に扁平苔癬型薬疹における免疫組織学的検索(シンポジウム 「薬剤アレルギーの現状」, 第415回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:54:44.415055+00:00"}