{"_buckets": {"deposit": "ce959450-ecdd-4dad-8fc5-07d17a2eaca2"}, "_deposit": {"id": "24204", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "24204"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00024204", "sets": ["456", "1235"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Electron Microscopic Study of Pericanalicular Microfilaments in the liver with Intrahepatic Cholestasis"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1987-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "266", "bibliographicPageStart": "258", "bibliographicVolumeNumber": "101", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Ultrastructural observation was made in the liver of 20 patients with acute intrahepatic cholestasis and rats with cholestasis induced by Na-taurolithocholate in order to elucidate the role of pericanalicular microfilaments on intrahepatic cholestasis. The correlation between the alterations of pericanalicular microfilaments and the alterations of bile canalicular membranes, their surface coat (ruthenium red-positive surface coat, RRSC) and membrane specific Mg^\u003c++\u003e-activated adenosine triphosphatase (Mg^\u003c++\u003e-ATPase) activity was examined. This study demonstrated that in acute intrahepatic cholestasis in men the shapes of pericanalicular microfilaments became shortened or granular at an early stage, and at the later stage they took the shapes of filamentous meshwork. The study also showed that in experimental cholestasis two types of bile canaliculi-one with shortened or granular pericanalicular microfilaments and the other with increased filamentous ones-were observed and RRSC and Mg^\u003c++\u003e-ATPase activity on both of them decreased. These findings suggest that dysfunction of pericanalicular microfilaments disturbs contractibility of bile canaliculus and can be a possible cause of intrahepatic cholestasis.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "144861", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kawamura, Tadashi"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "川村, 正"}], "nameIdentifiers": [{"nameIdentifier": "144860", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "101(4)_258-266.pdf", "filesize": [{"value": "3.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3100000.0, "url": {"label": "101(4)_258-266.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/24204/files/101(4)_258-266.pdf"}, "version_id": "a4aa820a-891e-4597-9ba9-d453643d5271"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "intrahepatic cholestasis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pericanalicular microfilaments", "subitem_subject_scheme": "Other"}, {"subitem_subject": "肝内胆汁うっ滞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "マイクロフィラメント", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "毛細胆管周囲性マイクロフィラメントに関する電子顕微鏡的研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "毛細胆管周囲性マイクロフィラメントに関する電子顕微鏡的研究"}, {"subitem_title": "毛細胆管周囲性マイクロフィラメントに関する電子顕微鏡的研究", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1235"], "permalink_uri": "http://hdl.handle.net/10191/36417", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-01-07"}, "publish_date": "2016-01-07", "publish_status": "0", "recid": "24204", "relation": {}, "relation_version_is_last": true, "title": ["毛細胆管周囲性マイクロフィラメントに関する電子顕微鏡的研究"], "weko_shared_id": null}