@article{oai:niigata-u.repo.nii.ac.jp:00024204,
 author = {川村, 正},
 issue = {4},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Apr},
 note = {Ultrastructural observation was made in the liver of 20 patients with acute intrahepatic cholestasis and rats with cholestasis induced by Na-taurolithocholate in order to elucidate the role of pericanalicular microfilaments on intrahepatic cholestasis. The correlation between the alterations of pericanalicular microfilaments and the alterations of bile canalicular membranes, their surface coat (ruthenium red-positive surface coat, RRSC) and membrane specific Mg^<++>-activated adenosine triphosphatase (Mg^<++>-ATPase) activity was examined. This study demonstrated that in acute intrahepatic cholestasis in men the shapes of pericanalicular microfilaments became shortened or granular at an early stage, and at the later stage they took the shapes of filamentous meshwork. The study also showed that in experimental cholestasis two types of bile canaliculi-one with shortened or granular pericanalicular microfilaments and the other with increased filamentous ones-were observed and RRSC and Mg^<++>-ATPase activity on both of them decreased. These findings suggest that dysfunction of pericanalicular microfilaments disturbs contractibility of bile canaliculus and can be a possible cause of intrahepatic cholestasis.},
 pages = {258--266},
 title = {毛細胆管周囲性マイクロフィラメントに関する電子顕微鏡的研究},
 volume = {101},
 year = {1987}
}