{"_buckets": {"deposit": "9c29c622-537b-4f7a-8d09-17b2411d3289"}, "_deposit": {"id": "24122", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "24122"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00024122"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Characterization of the surface antigens on human mononuclear cells to which anti-myelin associated glycoprotein (MAG) monoclonal antibodies bind"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1987-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "389", "bibliographicPageStart": "382", "bibliographicVolumeNumber": "101", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Three (GC-J4, MC-P2 and MC-P4) out of five murine monoclonal antibodies (mAbs) to myelin-associated glycoprotein (MAG) bound to human mononuclear cells (MNC). The results of the competitive inhibition assay suggested that MC-P2 and MC-P4 bind directly to or close to the Leu 7 epitope, and that GC-J4 binds to the epitope which is distinct from the Leu 7 epitope. The electrophoretic patterns of immunoprecipitates with GC-J4, MC-P2 and anti-Leu 7 from detergent lysates of surface labeled human MNC were very similar. The target molecules of anti-Leu 7, MC-P2 and GC-J4 have apparent molecular weights of 205, 170, 150, 135, 110, 85, 65 and 55 kDa, and they are monomeric or noncovalently associated proteins. The patterns of immunoprecipitates with MC-P4 were slightly different from those with anti-Leu 7 and MC-P2. The implications of these results are as follows: 1) The mAb with specificity to the carbohydrate part of MAG reacts with the Leu 7-reactive molecule on human MNC. 2) At least two epitopes detected by anti-MAG mAbs coexist on the surface molecules with various apparent molecular weights. 3) The fine antigenic specificity of MC-P4 is different from those of anti-Leu 7 or MC-P2.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "144533", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Arai, Motomi"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u8352\u4e95, \u5143\u7f8e"}], "nameIdentifiers": [{"nameIdentifier": "144532", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "101(6)_382-389.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "101(6)_382-389.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/24122/files/101(6)_382-389.pdf"}, "version_id": "96f12fb7-bcf7-433c-bb63-c3775810d18e"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "monoclonal antibody", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myelin-associated glycoprotein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mononuclear cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "surface marker", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30df\u30a8\u30ea\u30f3\u7cd6\u86cb\u767d", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30ea\u30f3\u30d1\u7403", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8868\u9762\u6297\u539f", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u6297Myelin-associated glycoprotein(MAG)\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3068\u7d50\u5408\u3059\u308b\u30d2\u30c8\u306e\u30ea\u30f3\u30d1\u7403\u8868\u9762\u6297\u539f\u306e\u89e3\u6790", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u6297Myelin-associated glycoprotein(MAG)\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3068\u7d50\u5408\u3059\u308b\u30d2\u30c8\u306e\u30ea\u30f3\u30d1\u7403\u8868\u9762\u6297\u539f\u306e\u89e3\u6790"}, {"subitem_title": "\u6297Myelin-associated glycoprotein(MAG)\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3068\u7d50\u5408\u3059\u308b\u30d2\u30c8\u306e\u30ea\u30f3\u30d1\u7403\u8868\u9762\u6297\u539f\u306e\u89e3\u6790", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1233"], "permalink_uri": "http://hdl.handle.net/10191/36481", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-01-07"}, "publish_date": "2016-01-07", "publish_status": "0", "recid": "24122", "relation": {}, "relation_version_is_last": true, "title": ["\u6297Myelin-associated glycoprotein(MAG)\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3068\u7d50\u5408\u3059\u308b\u30d2\u30c8\u306e\u30ea\u30f3\u30d1\u7403\u8868\u9762\u6297\u539f\u306e\u89e3\u6790"], "weko_shared_id": null}