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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第101巻第6号

抗Myelin-associated glycoprotein(MAG)モノクローナル抗体と結合するヒトのリンパ球表面抗原の解析

http://hdl.handle.net/10191/36481
http://hdl.handle.net/10191/36481
86344d52-3cb0-4105-89da-4cea4cd5e26f
名前 / ファイル ライセンス アクション
101(6)_382-389.pdf 101(6)_382-389.pdf (1.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-01-07
タイトル
タイトル 抗Myelin-associated glycoprotein(MAG)モノクローナル抗体と結合するヒトのリンパ球表面抗原の解析
タイトル
言語 en
タイトル 抗Myelin-associated glycoprotein(MAG)モノクローナル抗体と結合するヒトのリンパ球表面抗原の解析
言語
言語 jpn
キーワード
主題Scheme Other
主題 monoclonal antibody
キーワード
主題Scheme Other
主題 myelin-associated glycoprotein
キーワード
主題Scheme Other
主題 mononuclear cells
キーワード
主題Scheme Other
主題 surface marker
キーワード
主題Scheme Other
主題 モノクローナル抗体
キーワード
主題Scheme Other
主題 ミエリン糖蛋白
キーワード
主題Scheme Other
主題 リンパ球
キーワード
主題Scheme Other
主題 表面抗原
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Characterization of the surface antigens on human mononuclear cells to which anti-myelin associated glycoprotein (MAG) monoclonal antibodies bind
著者 荒井, 元美

× 荒井, 元美

WEKO 144532

荒井, 元美

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著者別名
識別子 144533
識別子Scheme WEKO
姓名 Arai, Motomi
抄録
内容記述タイプ Abstract
内容記述 Three (GC-J4, MC-P2 and MC-P4) out of five murine monoclonal antibodies (mAbs) to myelin-associated glycoprotein (MAG) bound to human mononuclear cells (MNC). The results of the competitive inhibition assay suggested that MC-P2 and MC-P4 bind directly to or close to the Leu 7 epitope, and that GC-J4 binds to the epitope which is distinct from the Leu 7 epitope. The electrophoretic patterns of immunoprecipitates with GC-J4, MC-P2 and anti-Leu 7 from detergent lysates of surface labeled human MNC were very similar. The target molecules of anti-Leu 7, MC-P2 and GC-J4 have apparent molecular weights of 205, 170, 150, 135, 110, 85, 65 and 55 kDa, and they are monomeric or noncovalently associated proteins. The patterns of immunoprecipitates with MC-P4 were slightly different from those with anti-Leu 7 and MC-P2. The implications of these results are as follows: 1) The mAb with specificity to the carbohydrate part of MAG reacts with the Leu 7-reactive molecule on human MNC. 2) At least two epitopes detected by anti-MAG mAbs coexist on the surface molecules with various apparent molecular weights. 3) The fine antigenic specificity of MC-P4 is different from those of anti-Leu 7 or MC-P2.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 101, 号 6, p. 382-389, 発行日 1987-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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