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Sera from both patients did not react with myelin-associated glycoprotein (MAG) which is known to be an antigen for some patients with IgM paraproteinemia and polyneuropathy. One patient\u0027s serum, who was diagnosed clinically as polyradiculoneuropathy reacted with a ganglioside, sialosyllactosaminylparagloboside (SLPG) in human peripheral nerve. The immunostaining was specific for K chain type, the same as the patient\u0027s paraprotein. Serum from the other patient, who was diagnosed as chronic relapsing ataxic polyneuropathy, reacted with G_\u003cM1\u003e ganglioside. The titers of anti-G_\u003cM1\u003e antibodies, examined by ELISA, decreased when his clinical signs, such as ataxic gait, were improved. In the patients of IgM paraproteinemia, these anti-ganglioside antibodies, anti-SLPG and anti-G_\u003cM1\u003e antibodies, have not been reported previously. These antibodies may play a role in the pathogenesis of neuropathy.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "142274", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Miyatani, Nobuyuki"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5bae\u8c37, \u4fe1\u884c"}], "nameIdentifiers": [{"nameIdentifier": "142273", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "101(12)_776-784.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "101(12)_776-784.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/23667/files/101(12)_776-784.pdf"}, "version_id": "438fb8a5-590a-4469-bd43-df970935e57e"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "IgM paraproteinemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neuropathy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ganglioside", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgM\u30d1\u30e9\u30d7\u30ed\u30c6\u30a4\u30f3\u8840\u75c7", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30ac\u30f3\u30b0\u30ea\u30aa\u30b5\u30a4\u30c9", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "IgM paraproteinemia\u3092\u3068\u3082\u306a\u3046polyneuropathy\u60a3\u8005\u8840\u6e05\u4e2d\u306e\u6297\u30ac\u30f3\u30b0\u30ea\u30aa\u30b5\u30a4\u30c9\u6297\u4f53\u306e\u691c\u7d22", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "IgM paraproteinemia\u3092\u3068\u3082\u306a\u3046polyneuropathy\u60a3\u8005\u8840\u6e05\u4e2d\u306e\u6297\u30ac\u30f3\u30b0\u30ea\u30aa\u30b5\u30a4\u30c9\u6297\u4f53\u306e\u691c\u7d22"}, {"subitem_title": "IgM paraproteinemia\u3092\u3068\u3082\u306a\u3046polyneuropathy\u60a3\u8005\u8840\u6e05\u4e2d\u306e\u6297\u30ac\u30f3\u30b0\u30ea\u30aa\u30b5\u30a4\u30c9\u6297\u4f53\u306e\u691c\u7d22", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1227"], "permalink_uri": "http://hdl.handle.net/10191/36963", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-01-14"}, "publish_date": "2016-01-14", "publish_status": "0", "recid": "23667", "relation": {}, "relation_version_is_last": true, "title": ["IgM paraproteinemia\u3092\u3068\u3082\u306a\u3046polyneuropathy\u60a3\u8005\u8840\u6e05\u4e2d\u306e\u6297\u30ac\u30f3\u30b0\u30ea\u30aa\u30b5\u30a4\u30c9\u6297\u4f53\u306e\u691c\u7d22"], "weko_shared_id": null}