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IgM paraproteinemiaをともなうpolyneuropathy患者血清中の抗ガングリオサイド抗体の検索
http://hdl.handle.net/10191/36963
http://hdl.handle.net/10191/36963c5a2012e-7e3c-41fa-a49e-660565520516
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
101(12)_776-784.pdf (1.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-01-14 | |||||
| タイトル | ||||||
| タイトル | IgM paraproteinemiaをともなうpolyneuropathy患者血清中の抗ガングリオサイド抗体の検索 | |||||
| タイトル | ||||||
| タイトル | IgM paraproteinemiaをともなうpolyneuropathy患者血清中の抗ガングリオサイド抗体の検索 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IgM paraproteinemia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neuropathy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ganglioside | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IgMパラプロテイン血症 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ガングリオサイド | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Anti-ganglioside Antibodies in Patients with IgM Paraproteinemia and Polyneuropathy | |||||
| 著者 |
宮谷, 信行
× 宮谷, 信行 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 142274 | |||||
| 姓名 | Miyatani, Nobuyuki | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | IgM fraction of in two patients with IgM paraproteinemia and peripheral neuropathy were shown to bind to human peripheral or central nerve gangliosides by immunostaining of thin layer chromatogram and enzyme-linked immunosorbent assay (ELISA). Sera from both patients did not react with myelin-associated glycoprotein (MAG) which is known to be an antigen for some patients with IgM paraproteinemia and polyneuropathy. One patient's serum, who was diagnosed clinically as polyradiculoneuropathy reacted with a ganglioside, sialosyllactosaminylparagloboside (SLPG) in human peripheral nerve. The immunostaining was specific for K chain type, the same as the patient's paraprotein. Serum from the other patient, who was diagnosed as chronic relapsing ataxic polyneuropathy, reacted with G_<M1> ganglioside. The titers of anti-G_<M1> antibodies, examined by ELISA, decreased when his clinical signs, such as ataxic gait, were improved. In the patients of IgM paraproteinemia, these anti-ganglioside antibodies, anti-SLPG and anti-G_<M1> antibodies, have not been reported previously. These antibodies may play a role in the pathogenesis of neuropathy. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 101, 号 12, p. 776-784, 発行日 1987-12 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
