{"created":"2021-03-01T06:28:56.945769+00:00","id":23667,"links":{},"metadata":{"_buckets":{"deposit":"91df3967-9c69-42ef-83a3-bcf16951b0c3"},"_deposit":{"id":"23667","owners":[],"pid":{"revision_id":0,"type":"depid","value":"23667"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00023667","sets":["453:456","471:537:538:1227"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Anti-ganglioside Antibodies in Patients with IgM Paraproteinemia and Polyneuropathy"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"784","bibliographicPageStart":"776","bibliographicVolumeNumber":"101","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"IgM fraction of in two patients with IgM paraproteinemia and peripheral neuropathy were shown to bind to human peripheral or central nerve gangliosides by immunostaining of thin layer chromatogram and enzyme-linked immunosorbent assay (ELISA). Sera from both patients did not react with myelin-associated glycoprotein (MAG) which is known to be an antigen for some patients with IgM paraproteinemia and polyneuropathy. One patient's serum, who was diagnosed clinically as polyradiculoneuropathy reacted with a ganglioside, sialosyllactosaminylparagloboside (SLPG) in human peripheral nerve. The immunostaining was specific for K chain type, the same as the patient's paraprotein. Serum from the other patient, who was diagnosed as chronic relapsing ataxic polyneuropathy, reacted with G_<M1> ganglioside. The titers of anti-G_<M1> antibodies, examined by ELISA, decreased when his clinical signs, such as ataxic gait, were improved. In the patients of IgM paraproteinemia, these anti-ganglioside antibodies, anti-SLPG and anti-G_<M1> antibodies, have not been reported previously. These antibodies may play a role in the pathogenesis of neuropathy.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"142274","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Miyatani, Nobuyuki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮谷, 信行"}],"nameIdentifiers":[{"nameIdentifier":"142273","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"101(12)_776-784.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"101(12)_776-784.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/23667/files/101(12)_776-784.pdf"},"version_id":"438fb8a5-590a-4469-bd43-df970935e57e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IgM paraproteinemia","subitem_subject_scheme":"Other"},{"subitem_subject":"neuropathy","subitem_subject_scheme":"Other"},{"subitem_subject":"ganglioside","subitem_subject_scheme":"Other"},{"subitem_subject":"IgMパラプロテイン血症","subitem_subject_scheme":"Other"},{"subitem_subject":"ガングリオサイド","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"IgM paraproteinemiaをともなうpolyneuropathy患者血清中の抗ガングリオサイド抗体の検索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IgM paraproteinemiaをともなうpolyneuropathy患者血清中の抗ガングリオサイド抗体の検索"},{"subitem_title":"IgM paraproteinemiaをともなうpolyneuropathy患者血清中の抗ガングリオサイド抗体の検索","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1227"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-14"},"publish_date":"2016-01-14","publish_status":"0","recid":"23667","relation_version_is_last":true,"title":["IgM paraproteinemiaをともなうpolyneuropathy患者血清中の抗ガングリオサイド抗体の検索"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:53:50.627286+00:00"}