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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第102巻第7号

重症感染症下のブドウ糖代謝動態に関する研究 : エンドトキシン投与犬での実験

http://hdl.handle.net/10191/40855
http://hdl.handle.net/10191/40855
22313d87-bad1-44ac-8b2d-1dfbfc0d0759
名前 / ファイル ライセンス アクション
102(7)_405-419.pdf 102(7)_405-419.pdf (2.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-04-06
タイトル
タイトル 重症感染症下のブドウ糖代謝動態に関する研究 : エンドトキシン投与犬での実験
タイトル
言語 en
タイトル 重症感染症下のブドウ糖代謝動態に関する研究 : エンドトキシン投与犬での実験
言語
言語 jpn
キーワード
主題Scheme Other
主題 endotoxemia
キーワード
主題Scheme Other
主題 glucose kinetics
キーワード
主題Scheme Other
主題 primed constant infusion 法
キーワード
主題Scheme Other
主題 エンドトキシン血症
キーワード
主題Scheme Other
主題 ブドウ糖代謝動態
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Glucose Kinetics in Dogs Following E. coli Endotoxin Injection
著者 小林, 孝

× 小林, 孝

WEKO 141009

小林, 孝

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著者別名
識別子 141010
識別子Scheme WEKO
姓名 Kobayashi, Takashi
抄録
内容記述タイプ Abstract
内容記述 The contribution of hindlimb glucose consumption to that of whole body, and the whole body glucose kinetics in dogs after endotoxin (Et) administration were investigated. Mongrel dogs in control (C) group received continuous infusion of pentobarbital sodium at the rate of 5mg /k/hr. A bolus of 3mg/kg of E. coli lipopolysaccharide was injected to the dogs in group E in addition to the pentobarbital infusion. Femoral arterial blood flow (FABF) and arterio-venous differences (A-V diff.) of glucose, lactate, and alanine were measured, and the net hindlimb glucose uptake (or release) of these substrates was calculated using multiplication of the A-V diff. by corresponding FABF. Endogenous glucose production rate (Ra), glucose disappearance rate (Rd), and glucose oxidation rate (Rox) were determined by the simultaneous primed constant infusion of [6-^3H] and [U-^<14>C] glucose. Two additional indices for the tissue ability of glucose oxidation, i.e., % Vco2 from glucose and % of Rd oxidized were also calculated. E group showed significant increase of the net glucose uptake by hindlimb, while the net release of lactate and alanine were not changed by the Et injection. Ra, Rd, and Rox were significantly increased after Et administration. Conclusions of the present study are 1) Cori cycle and glucose-alanine cycle between the liver and the skeletal muscle is not contributing to the enhanced gluconeoenesis in the liver, and 2) the increase of peripheral glucose uptake enhances the whole body glucose oxidation after Et injection, because the ability of peripheral tissue to oxidize unit amount of glucose is not impaired.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 102, 号 7, p. 405-419, 発行日 1988-07
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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