@article{oai:niigata-u.repo.nii.ac.jp:00023411,
 author = {小林, 孝},
 issue = {7},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jul},
 note = {The contribution of hindlimb glucose consumption to that of whole body, and the whole body glucose kinetics in dogs after endotoxin (Et) administration were investigated. Mongrel dogs in control (C) group received continuous infusion of pentobarbital sodium at the rate of 5mg /k/hr. A bolus of 3mg/kg of E. coli lipopolysaccharide was injected to the dogs in group E in addition to the pentobarbital infusion. Femoral arterial blood flow (FABF) and arterio-venous differences (A-V diff.) of glucose, lactate, and alanine were measured, and the net hindlimb glucose uptake (or release) of these substrates was calculated using multiplication of the A-V diff. by corresponding FABF. Endogenous glucose production rate (Ra), glucose disappearance rate (Rd), and glucose oxidation rate (Rox) were determined by the simultaneous primed constant infusion of [6-^3H] and [U-^<14>C] glucose. Two additional indices for the tissue ability of glucose oxidation, i.e., % Vco2 from glucose and % of Rd oxidized were also calculated. E group showed significant increase of the net glucose uptake by hindlimb, while the net release of lactate and alanine were not changed by the Et injection. Ra, Rd, and Rox were significantly increased after Et administration. Conclusions of the present study are 1) Cori cycle and glucose-alanine cycle between the liver and the skeletal muscle is not contributing to the enhanced gluconeoenesis in the liver, and 2) the increase of peripheral glucose uptake enhances the whole body glucose oxidation after Et injection, because the ability of peripheral tissue to oxidize unit amount of glucose is not impaired.},
 pages = {405--419},
 title = {重症感染症下のブドウ糖代謝動態に関する研究 : エンドトキシン投与犬での実験},
 volume = {102},
 year = {1988}
}