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Recently, both the factor VIII and the factor IX genes have been cloned and well characterized, and three and five intragenic RFLPs (restriction fragment length polymorphisms) of the factor VIII and the factor IX genes, respectively, have been identified. These RFLPs can be successfully used for prenatal diagnosis and carrier detection of hemophilia A. DNA diagnosis of hemophilia B in Japanese, however, is not successful due to the absence of common polymorphisms thus far identified in Caucasians.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "138325", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Koide, Takehiko"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5c0f\u51fa, \u6b66\u6bd4\u53e4"}], "nameIdentifiers": [{"nameIdentifier": "138324", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "103(6)_457-461.pdf", "filesize": [{"value": "998.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 998900.0, "url": {"label": "103(6)_457-461.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/22874/files/103(6)_457-461.pdf"}, "version_id": "3d3e0bbd-cda8-4377-b513-007411f8102c"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "RFLP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DNA diagnosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prenatal diagnosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "carrier detection", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hemophilias", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u591a\u578b\u6027", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DNA\u8a3a\u65ad", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u80ce\u5150\u8a3a\u65ad", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u4fdd\u56e0\u8005\u8a3a\u65ad", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8840\u53cb\u75c5", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "5) \u8840\u53cb\u75c5\u306eDNA\u8a3a\u65ad(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u907a\u4f1d\u5b50\u5de5\u5b66\u306b\u3088\u308b\u75c5\u56e0\u89e3\u6790\u3068\u305d\u306e\u8a3a\u65ad, \u7b2c435\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "5) \u8840\u53cb\u75c5\u306eDNA\u8a3a\u65ad(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u907a\u4f1d\u5b50\u5de5\u5b66\u306b\u3088\u308b\u75c5\u56e0\u89e3\u6790\u3068\u305d\u306e\u8a3a\u65ad, \u7b2c435\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"}, {"subitem_title": "5) \u8840\u53cb\u75c5\u306eDNA\u8a3a\u65ad(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u907a\u4f1d\u5b50\u5de5\u5b66\u306b\u3088\u308b\u75c5\u56e0\u89e3\u6790\u3068\u305d\u306e\u8a3a\u65ad, \u7b2c435\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1209"], "permalink_uri": "http://hdl.handle.net/10191/41293", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-04-11"}, "publish_date": "2016-04-11", "publish_status": "0", "recid": "22874", "relation": {}, "relation_version_is_last": true, "title": ["5) \u8840\u53cb\u75c5\u306eDNA\u8a3a\u65ad(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u907a\u4f1d\u5b50\u5de5\u5b66\u306b\u3088\u308b\u75c5\u56e0\u89e3\u6790\u3068\u305d\u306e\u8a3a\u65ad, \u7b2c435\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"], "weko_shared_id": null}