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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第103巻第7号

夫婦間リンパ球混合培養遮断抗体に対応する絨毛細胞膜抗原の解析

http://hdl.handle.net/10191/41334
http://hdl.handle.net/10191/41334
9b57ecf5-5f1d-4429-9873-df02c789af5c
名前 / ファイル ライセンス アクション
103(7)_549-555.pdf 103(7)_549-555.pdf (1.5 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-04-11
タイトル
タイトル 夫婦間リンパ球混合培養遮断抗体に対応する絨毛細胞膜抗原の解析
タイトル
言語 en
タイトル 夫婦間リンパ球混合培養遮断抗体に対応する絨毛細胞膜抗原の解析
言語
言語 jpn
キーワード
主題Scheme Other
主題 trophoblast
キーワード
主題Scheme Other
主題 blocking antibodies
キーワード
主題Scheme Other
主題 mixed lymphocyte reaction
キーワード
主題Scheme Other
主題 絨毛細胞
キーワード
主題Scheme Other
主題 遮断抗体
キーワード
主題Scheme Other
主題 リンパ球混合培養
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Studies on the Antigens Expressed on Trophoblasts Related to MLR-blocking Antibodies
著者 後藤, 重則

× 後藤, 重則

WEKO 138182

後藤, 重則

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著者別名
識別子 138183
識別子Scheme WEKO
姓名 Goto, Shigenori
抄録
内容記述タイプ Abstract
内容記述 The purpose of this study is to investigate the antigenic nature of trophoblasts and its relation to mixed lymphocyte reaction-blocking antibodies (MLR-BAbs). Mixed culture of lymphocytes and syncytiotrophoblasts plasma membrane (STPM) (MLSC) and absorption study of MLR-blocking effect with STPM were perfomed in the present experiments. Lymphocytes were obviously stimulated in the 9 MLSCs. And like MLR, this stimulation was specifically inhibited by corresponding mothers' sera, suggesting that lymphocytes were stimulated in MLSCs by alloantigens expressed on STPM. Nineteen sera were obtained from normal pregnant women and habitual aborters after immunotherapy. And these sera were absorbed with STPM from respective mothers' placenta (autologous STPM) and unrelated mothers' (allogeneic STPM) as a control. The HLA types of cord blood lymphocytes corresponding to these STPM were then determined. The MLR-blocking effect of every serum was removed by autologous STPM absorption, nevertheless it was removed or unaffected by allogeneic one. Comparison of paternal stimulator and cord blood lymphocytes HLA-PR types showed that some of positive absorptions with allogeneic STPM could be explained by coincidence of HLA-DR types. These findings suggested that MLR-BAbs were directed against some alloantigens expressed on trophoblasts that might be related to HLA-DR antigens.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 103, 号 7, p. 549-555, 発行日 1989-07
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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