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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第103巻第7号

潰瘍性大腸炎の免疫異常

http://hdl.handle.net/10191/41331
http://hdl.handle.net/10191/41331
239a7468-6915-4e7a-9fda-7eb31612b514
名前 / ファイル ライセンス アクション
103(7)_541-548.pdf 103(7)_541-548.pdf (1.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-04-11
タイトル
タイトル 潰瘍性大腸炎の免疫異常
タイトル
言語 en
タイトル 潰瘍性大腸炎の免疫異常
言語
言語 jpn
キーワード
主題Scheme Other
主題 潰瘍性大腸炎
キーワード
主題Scheme Other
主題 免疫異常
キーワード
主題Scheme Other
主題 胸腺
キーワード
主題Scheme Other
主題 HLA-DR2
キーワード
主題Scheme Other
主題 抗大腸抗体
キーワード
主題Scheme Other
主題 ADCC
キーワード
主題Scheme Other
主題 suppressor T cell
キーワード
主題Scheme Other
主題 interleukin 2 (IL 2)
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Immunological Abnormalities in Ulcerative Colitis
著者 朝倉, 均

× 朝倉, 均

WEKO 138180

朝倉, 均

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著者別名
識別子 138181
識別子Scheme WEKO
姓名 Asakura, Hitoshi
抄録
内容記述タイプ Abstract
内容記述 Ulcerative colitis is a nonspecific inflammatory colonic disease and an intractable disorder. Pathogenesis of this disorder is not fully clarified and there are many studies suggesting that abnormalities in humor al and cellular immunity might play some roles in disease chronicity and intractability of ulcerative colitis. More than 70% of the patients with ulcerative colitis had a certain disposition to have HLA-DR 2 antigen as an immunoresponse gene, and autoantibodies such as anti-colon antibody and lymphocytophilic antibody were detected in the serum of more than 70% of the patients. Anti-colon antibody played a role in antibody dependent cell-mediated cytotoxicity against the colonic mucosal epithelium. Thymic abnormalitis in ulcerative colitis were demonstrated by pneumomediastinography and immunohistochemical study that there were present immature thymocytes and B cells in the ulcerative colitis thymus. Immunohistochemical study on the ulcerative colitis mucosa revealed marked increases in CD4 positive lymphocytes and IgG-containing cells. EB virus-transformed B cells from the colonic mucosa and peripheral blood of the patients with ulcerative colitis produced anti-colon antibody, probably due to an impaired suppressor T cell activity.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 103, 号 7, p. 541-548, 発行日 1989-07
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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