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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第104巻第6号

慢性骨髄性白血病におけるインターフェロン-α添加骨髄長期培養によるPh^1陽性クローンの選択的除去と自家骨髄移植への応用

http://hdl.handle.net/10191/34210
http://hdl.handle.net/10191/34210
f9fa1f5b-12d4-418f-b3e5-e53ab9fa1b38
名前 / ファイル ライセンス アクション
104(6)_508-517.pdf 104(6)_508-517.pdf (2.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-11-11
タイトル
タイトル 慢性骨髄性白血病におけるインターフェロン-α添加骨髄長期培養によるPh^1陽性クローンの選択的除去と自家骨髄移植への応用
タイトル
言語 en
タイトル 慢性骨髄性白血病におけるインターフェロン-α添加骨髄長期培養によるPh^1陽性クローンの選択的除去と自家骨髄移植への応用
言語
言語 jpn
キーワード
主題Scheme Other
主題 autologous bone marrow transplantation
キーワード
主題Scheme Other
主題 interferon-α : INF-α
キーワード
主題Scheme Other
主題 long term marrow culture : LTMC
キーワード
主題Scheme Other
主題 chronic myelogenous leukemia : CML
キーワード
主題Scheme Other
主題 自家骨髄移植
キーワード
主題Scheme Other
主題 インターフェロン-α
キーワード
主題Scheme Other
主題 骨髄長期培養
キーワード
主題Scheme Other
主題 慢性骨髄性白血病
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Purging of ph^1 Positive Cells in CML by a Combination with Long Term Marrow Culture and Interferon-α and its Application to Autologous Bone Marrow Transplantation
著者 成田, 美和子

× 成田, 美和子

WEKO 134933

成田, 美和子

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著者別名
識別子 134934
識別子Scheme WEKO
姓名 Narita, Miwako
抄録
内容記述タイプ Abstract
内容記述 For the treatment of CML, bone marrow transplantation is thougt to be the only method that consistently restores normal hematopoiesis for long period. However, the indication of allogeneic marrow transplantation is restricted to a small number of patients with CML. As functionally competent Ph^1 negative hematopoietic stem cells are now known to persist in CML, autologous marrow transplantation might be undertaken with curative intent if clonogenic malignant (Ph^1 positive) stem cells could be eliminated from the autograft. For the purpose of developing a effective method to purge Ph^1 positive stem cells, we tried long term CML marrow culture in combination with IFN-α that is clinically established as a drug to inhibit the proliferation of Ph^1 positive cells. The long term culture in the presence of IFN-α (10~10^3 lU/ml) was found to eradicate Ph^1 positive CFU-GM derived colony forming cells in all CML patients in time and dose dependent manner. The effects of IFN-α to the microenvironment and to Ph^1 positive cells are still not so well analysed, but our results suggest that Ph^1 negative CFU-GM are more tolerable than Ph^1 positive ones in long term culture system with IFN-α. Thus, this culture system might be useful method to purging malignant (Ph^1 positive) clone for autologous marrow transplantation in patients with CML.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 104, 号 6, p. 508-517, 発行日 1990-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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