{"_buckets": {"deposit": "30510a31-9814-41d3-9942-aa07cc538dbc"}, "_deposit": {"id": "22188", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "22188"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00022188"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Mechanism of Resistance for Cytosine Arabinoside of AraC Resistance Leukemic Cell Line and a Specific Monoclonal Reacting with it(Clinical Application of Tumor Antigen)"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1990-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "460", "bibliographicPageStart": "454", "bibliographicVolumeNumber": "104", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We have established human leukemic cell lines, designated as KY-Ra and KY-Rb, which are highly resistant for cytosine arabinoside (AraC) and behenosyl AraC. Intercellular AraC increased in proportion to incubation time in parental KY-821, whereas did not increase in resistant cell lines. Intracellular AraC excluded in the extracellular medium in short time on KY-Ra and KY-Rb. Activity of deoxycytidine kinase was not so different in each cell line. We also obtained one hybridoma which secretes an antibody reacting with only resistant cell lines, although definite characterization has yet determined. NNatural IL-1, INF\u03b3, and TNF\u03b1 inhibited the proliferation of KY-821. In contrast natural IL-1 promoted ^3H-thymidine uptake of KY-Ra and KY-Rb, and no suppressive effect of IFN\u03b3 and TNF\u03b1 was observed in other cell lines. These results indicate that AraC efflux was attributable to unknown membrane protein probably distinct from P-glycoprotein and a different reactivity between resistant and non-resistant cell lines for growth factors is also owing to some changes of cell membrane.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "134888", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Fukuda, Takeaki"}]}, {"nameIdentifiers": [{"nameIdentifier": "134889", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kakihara, Toshio"}]}, {"nameIdentifiers": [{"nameIdentifier": "134890", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yamada, Toshiyuki"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": 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