ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "30510a31-9814-41d3-9942-aa07cc538dbc"}, "_deposit": {"id": "22188", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "22188"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00022188", "sets": ["456", "1197"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Mechanism of Resistance for Cytosine Arabinoside of AraC Resistance Leukemic Cell Line and a Specific Monoclonal Reacting with it(Clinical Application of Tumor Antigen)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1990-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "460", "bibliographicPageStart": "454", "bibliographicVolumeNumber": "104", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We have established human leukemic cell lines, designated as KY-Ra and KY-Rb, which are highly resistant for cytosine arabinoside (AraC) and behenosyl AraC. Intercellular AraC increased in proportion to incubation time in parental KY-821, whereas did not increase in resistant cell lines. Intracellular AraC excluded in the extracellular medium in short time on KY-Ra and KY-Rb. Activity of deoxycytidine kinase was not so different in each cell line. We also obtained one hybridoma which secretes an antibody reacting with only resistant cell lines, although definite characterization has yet determined. NNatural IL-1, INFγ, and TNFα inhibited the proliferation of KY-821. In contrast natural IL-1 promoted ^3H-thymidine uptake of KY-Ra and KY-Rb, and no suppressive effect of IFNγ and TNFα was observed in other cell lines. These results indicate that AraC efflux was attributable to unknown membrane protein probably distinct from P-glycoprotein and a different reactivity between resistant and non-resistant cell lines for growth factors is also owing to some changes of cell membrane.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "134888", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Fukuda, Takeaki"}]}, {"nameIdentifiers": [{"nameIdentifier": "134889", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kakihara, Toshio"}]}, {"nameIdentifiers": [{"nameIdentifier": "134890", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yamada, Toshiyuki"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "福田, 剛明"}], "nameIdentifiers": [{"nameIdentifier": "134885", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "柿原, 敏夫"}], "nameIdentifiers": [{"nameIdentifier": "134886", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田, 俊幸"}], "nameIdentifiers": [{"nameIdentifier": "134887", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "104(6)_454-460.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "104(6)_454-460.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/22188/files/104(6)_454-460.pdf"}, "version_id": "8233ce45-72f5-45e7-ac9e-ca856f0c2ce6"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "AraC resistance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "leukemic cell line", "subitem_subject_scheme": "Other"}, {"subitem_subject": "drug efflux", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cell membrane", "subitem_subject_scheme": "Other"}, {"subitem_subject": "AraC 耐性", "subitem_subject_scheme": "Other"}, {"subitem_subject": "白血病細胞株", "subitem_subject_scheme": "Other"}, {"subitem_subject": "薬剤排泄", "subitem_subject_scheme": "Other"}, {"subitem_subject": "細胞膜", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)"}, {"subitem_title": "1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1197"], "permalink_uri": "http://hdl.handle.net/10191/34212", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-11-11"}, "publish_date": "2015-11-11", "publish_status": "0", "recid": "22188", "relation": {}, "relation_version_is_last": true, "title": ["1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)"], "weko_shared_id": null}
  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第104巻第6号

1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)

http://hdl.handle.net/10191/34212
http://hdl.handle.net/10191/34212
0a77b4d6-3100-40d6-82fb-69bdc419c2b0
名前 / ファイル ライセンス アクション
104(6)_454-460.pdf 104(6)_454-460.pdf (1.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-11-11
タイトル
タイトル 1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)
タイトル
言語 en
タイトル 1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)
言語
言語 jpn
キーワード
主題Scheme Other
主題 AraC resistance
キーワード
主題Scheme Other
主題 leukemic cell line
キーワード
主題Scheme Other
主題 drug efflux
キーワード
主題Scheme Other
主題 cell membrane
キーワード
主題Scheme Other
主題 AraC 耐性
キーワード
主題Scheme Other
主題 白血病細胞株
キーワード
主題Scheme Other
主題 薬剤排泄
キーワード
主題Scheme Other
主題 細胞膜
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Mechanism of Resistance for Cytosine Arabinoside of AraC Resistance Leukemic Cell Line and a Specific Monoclonal Reacting with it(Clinical Application of Tumor Antigen)
著者 福田, 剛明

× 福田, 剛明

WEKO 134885

福田, 剛明

Search repository
柿原, 敏夫

× 柿原, 敏夫

WEKO 134886

柿原, 敏夫

Search repository
山田, 俊幸

× 山田, 俊幸

WEKO 134887

山田, 俊幸

Search repository
著者別名
識別子 134888
識別子Scheme WEKO
姓名 Fukuda, Takeaki
著者別名
識別子 134889
識別子Scheme WEKO
姓名 Kakihara, Toshio
著者別名
識別子 134890
識別子Scheme WEKO
姓名 Yamada, Toshiyuki
抄録
内容記述タイプ Abstract
内容記述 We have established human leukemic cell lines, designated as KY-Ra and KY-Rb, which are highly resistant for cytosine arabinoside (AraC) and behenosyl AraC. Intercellular AraC increased in proportion to incubation time in parental KY-821, whereas did not increase in resistant cell lines. Intracellular AraC excluded in the extracellular medium in short time on KY-Ra and KY-Rb. Activity of deoxycytidine kinase was not so different in each cell line. We also obtained one hybridoma which secretes an antibody reacting with only resistant cell lines, although definite characterization has yet determined. NNatural IL-1, INFγ, and TNFα inhibited the proliferation of KY-821. In contrast natural IL-1 promoted ^3H-thymidine uptake of KY-Ra and KY-Rb, and no suppressive effect of IFNγ and TNFα was observed in other cell lines. These results indicate that AraC efflux was attributable to unknown membrane protein probably distinct from P-glycoprotein and a different reactivity between resistant and non-resistant cell lines for growth factors is also owing to some changes of cell membrane.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 104, 号 6, p. 454-460, 発行日 1990-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 13:24:30.358649
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3