{"created":"2021-03-01T06:27:19.262999+00:00","id":22188,"links":{},"metadata":{"_buckets":{"deposit":"30510a31-9814-41d3-9942-aa07cc538dbc"},"_deposit":{"id":"22188","owners":[],"pid":{"revision_id":0,"type":"depid","value":"22188"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00022188","sets":["453:456","471:537:538:1197"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Mechanism of Resistance for Cytosine Arabinoside of AraC Resistance Leukemic Cell Line and a Specific Monoclonal Reacting with it(Clinical Application of Tumor Antigen)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"460","bibliographicPageStart":"454","bibliographicVolumeNumber":"104","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have established human leukemic cell lines, designated as KY-Ra and KY-Rb, which are highly resistant for cytosine arabinoside (AraC) and behenosyl AraC. Intercellular AraC increased in proportion to incubation time in parental KY-821, whereas did not increase in resistant cell lines. Intracellular AraC excluded in the extracellular medium in short time on KY-Ra and KY-Rb. Activity of deoxycytidine kinase was not so different in each cell line. We also obtained one hybridoma which secretes an antibody reacting with only resistant cell lines, although definite characterization has yet determined. NNatural IL-1, INFγ, and TNFα inhibited the proliferation of KY-821. In contrast natural IL-1 promoted ^3H-thymidine uptake of KY-Ra and KY-Rb, and no suppressive effect of IFNγ and TNFα was observed in other cell lines. These results indicate that AraC efflux was attributable to unknown membrane protein probably distinct from P-glycoprotein and a different reactivity between resistant and non-resistant cell lines for growth factors is also owing to some changes of cell membrane.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"134888","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fukuda, Takeaki"}]},{"nameIdentifiers":[{"nameIdentifier":"134889","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kakihara, Toshio"}]},{"nameIdentifiers":[{"nameIdentifier":"134890","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamada, Toshiyuki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福田, 剛明"}],"nameIdentifiers":[{"nameIdentifier":"134885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿原, 敏夫"}],"nameIdentifiers":[{"nameIdentifier":"134886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 俊幸"}],"nameIdentifiers":[{"nameIdentifier":"134887","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"104(6)_454-460.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"104(6)_454-460.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/22188/files/104(6)_454-460.pdf"},"version_id":"8233ce45-72f5-45e7-ac9e-ca856f0c2ce6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"AraC resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"leukemic cell line","subitem_subject_scheme":"Other"},{"subitem_subject":"drug efflux","subitem_subject_scheme":"Other"},{"subitem_subject":"cell membrane","subitem_subject_scheme":"Other"},{"subitem_subject":"AraC 耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"白血病細胞株","subitem_subject_scheme":"Other"},{"subitem_subject":"薬剤排泄","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞膜","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製（シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製（シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会）"},{"subitem_title":"1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製（シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会）","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1197"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-11"},"publish_date":"2015-11-11","publish_status":"0","recid":"22188","relation_version_is_last":true,"title":["1) AraC 耐性白血病細胞株の耐性機序と特異抗体の作製（シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会）"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:52:34.689136+00:00"}