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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第104巻第6号

インスリン様増殖因子(IGF)-IIの組織分布の特異性とそのin vitro活性

http://hdl.handle.net/10191/34208
http://hdl.handle.net/10191/34208
5200bffa-15ae-4f25-b595-a44d87f335ff
名前 / ファイル ライセンス アクション
104(6)_447-453.pdf 104(6)_447-453.pdf (2.5 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-11-11
タイトル
タイトル インスリン様増殖因子(IGF)-IIの組織分布の特異性とそのin vitro活性
タイトル
言語 en
タイトル インスリン様増殖因子(IGF)-IIの組織分布の特異性とそのin vitro活性
言語
言語 jpn
キーワード
主題Scheme Other
主題 IGF-II
キーワード
主題Scheme Other
主題 paraganglionic cell
キーワード
主題Scheme Other
主題 paraganglioma
キーワード
主題Scheme Other
主題 nerve growth factor
キーワード
主題Scheme Other
主題 インスリン様増殖因子-II
キーワード
主題Scheme Other
主題 旁神経節
キーワード
主題Scheme Other
主題 旁神経節腫
キーワード
主題Scheme Other
主題 神経成長因子
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Selective Localization of Insulin-like Growth factor (IGF)-II Immunoreactivity in human tissues and in vitro activity of IGF-II
著者 鈴木, 利光

× 鈴木, 利光

WEKO 134883

鈴木, 利光

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著者別名
識別子 134884
識別子Scheme WEKO
姓名 Suzuki, Toshimitsu
抄録
内容記述タイプ Abstract
内容記述 Insulin-like growth factor (IGF)-II immunoreactivity in human tissues was detected with use of monoclonal antibody against rat IGF-II, which crossreacts to human IGF-II. The results indicated that IGF-II immunoreactivity localized selectively in normal paraganglionic cells including carotid body, adrenal medulla and retroperitoneal paraganglion. In addition, fetal kidney of 14th gestational week revealed IGF-II immunoreactivity in limited proximal convolution to its beginning segment. Other tissues were regularly negative for the immunoreactivity. All of 29 tumors originated from this paraganglionic system harbored IGF-II immunoreactive tumor cells with high frequency, although one tumor of glomus jugulare in origin failed to immunolabelling. IGF-II induced morphological differentiation of rat pheochromocytoma cell line PC 12 and also enhanced cell growth of human neuroblastoma cell line NB-45-nu F in vitro, as potent as nerve growth factor which caused same effects on these two cell lines. From these results, IGF-II might be a kind of nerve growth factor of human paraganglionic system.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 104, 号 6, p. 447-453, 発行日 1990-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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