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The results indicated that IGF-II immunoreactivity localized selectively in normal paraganglionic cells including carotid body, adrenal medulla and retroperitoneal paraganglion. In addition, fetal kidney of 14th gestational week revealed IGF-II immunoreactivity in limited proximal convolution to its beginning segment. Other tissues were regularly negative for the immunoreactivity. All of 29 tumors originated from this paraganglionic system harbored IGF-II immunoreactive tumor cells with high frequency, although one tumor of glomus jugulare in origin failed to immunolabelling. IGF-II induced morphological differentiation of rat pheochromocytoma cell line PC 12 and also enhanced cell growth of human neuroblastoma cell line NB-45-nu F in vitro, as potent as nerve growth factor which caused same effects on these two cell lines. From these results, IGF-II might be a kind of nerve growth factor of human paraganglionic system.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "134884", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Suzuki, Toshimitsu"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u9234\u6728, \u5229\u5149"}], "nameIdentifiers": [{"nameIdentifier": "134883", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "104(6)_447-453.pdf", "filesize": [{"value": "2.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2500000.0, "url": {"label": "104(6)_447-453.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/22187/files/104(6)_447-453.pdf"}, "version_id": "67befcb1-9e2e-4715-ae42-9fe40e203492"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "IGF-II", "subitem_subject_scheme": "Other"}, {"subitem_subject": "paraganglionic cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "paraganglioma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nerve growth factor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u5897\u6b96\u56e0\u5b50-II", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u65c1\u795e\u7d4c\u7bc0", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u65c1\u795e\u7d4c\u7bc0\u816b", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u795e\u7d4c\u6210\u9577\u56e0\u5b50", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u5897\u6b96\u56e0\u5b50(IGF)-II\u306e\u7d44\u7e54\u5206\u5e03\u306e\u7279\u7570\u6027\u3068\u305d\u306ein vitro\u6d3b\u6027", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u5897\u6b96\u56e0\u5b50(IGF)-II\u306e\u7d44\u7e54\u5206\u5e03\u306e\u7279\u7570\u6027\u3068\u305d\u306ein vitro\u6d3b\u6027"}, {"subitem_title": "\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u5897\u6b96\u56e0\u5b50(IGF)-II\u306e\u7d44\u7e54\u5206\u5e03\u306e\u7279\u7570\u6027\u3068\u305d\u306ein vitro\u6d3b\u6027", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1197"], "permalink_uri": "http://hdl.handle.net/10191/34208", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-11-11"}, "publish_date": "2015-11-11", "publish_status": "0", "recid": "22187", "relation": {}, "relation_version_is_last": true, "title": ["\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u5897\u6b96\u56e0\u5b50(IGF)-II\u306e\u7d44\u7e54\u5206\u5e03\u306e\u7279\u7570\u6027\u3068\u305d\u306ein vitro\u6d3b\u6027"], "weko_shared_id": null}