@article{oai:niigata-u.repo.nii.ac.jp:00022187,
 author = {鈴木, 利光},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {Insulin-like growth factor (IGF)-II immunoreactivity in human tissues was detected with use of monoclonal antibody against rat IGF-II, which crossreacts to human IGF-II. The results indicated that IGF-II immunoreactivity localized selectively in normal paraganglionic cells including carotid body, adrenal medulla and retroperitoneal paraganglion. In addition, fetal kidney of 14th gestational week revealed IGF-II immunoreactivity in limited proximal convolution to its beginning segment. Other tissues were regularly negative for the immunoreactivity. All of 29 tumors originated from this paraganglionic system harbored IGF-II immunoreactive tumor cells with high frequency, although one tumor of glomus jugulare in origin failed to immunolabelling. IGF-II induced morphological differentiation of rat pheochromocytoma cell line PC 12 and also enhanced cell growth of human neuroblastoma cell line NB-45-nu F in vitro, as potent as nerve growth factor which caused same effects on these two cell lines. From these results, IGF-II might be a kind of nerve growth factor of human paraganglionic system.},
 pages = {447--453},
 title = {インスリン様増殖因子(IGF)-IIの組織分布の特異性とそのin vitro活性},
 volume = {104},
 year = {1990}
}