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Down症候群の新生児にみられたtransient abnormal myelopoiesis（TAM）8例の臨床像（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み）
http://hdl.handle.net/10191/34477
http://hdl.handle.net/10191/34477419b3837-90ea-45e8-aac3-486e7770f070
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
104(7)_593-597.pdf (1.5 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-11-16 | |||||
| タイトル | ||||||
| タイトル | Down症候群の新生児にみられたtransient abnormal myelopoiesis（TAM）8例の臨床像（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み） | |||||
| タイトル | ||||||
| タイトル | Down症候群の新生児にみられたtransient abnormal myelopoiesis（TAM）8例の臨床像（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み） | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Transient Abnormal Myelopoiesis (TAM) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Down症候群 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PPO or Gp IIb/IIIa 陽性 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 染色体分析 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | コロニー形成能 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Clinical Studies on 8 cases Transient Abnormal Myelopoiesis with Down Syndrome(20th Meeting of the Niigata Society of Hematologic Neoplasm The Ten-year Anniversary Symposium : Progress in Hematologic Neoplasm over the Ten Years) | |||||
| 著者 |
石塚, 利江
× 石塚, 利江× 小田, 良彦× 高井, 和江× 真田, 雅好× 岡崎, 悦夫 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 134828 | |||||
| 姓名 | Ishizuka, Toshie | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 134829 | |||||
| 姓名 | Oda, Yosihiko | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 134830 | |||||
| 姓名 | Takai, Kazue | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 134831 | |||||
| 姓名 | Sanada, Masayosi | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 134832 | |||||
| 姓名 | Okazaki, Etuo | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Transient abnormal myelopoiesis (TAM) with Down Syndrome is characterized by increased blast cells and resembles acute congenital leukemia. This disorder is unique in the point that the hematological abnormality is self-limiting. However, the association between TAM and the subsequent development of acute leukemia is not rully understood. We studied 8 patients of TAM with Down syndrome hospitalized during the recent 7 years. Clinical features of all patients were mostly compatible with the criteria proposed by Nagao, et al. Three had non immune hydorps fetalis (NIHF), two heart anomalies, one pulmonary leukostasis, two liver dysfunction, and two pancytopenia. Two died of NIHF after blast cells had disappeared and the other 6 are alive and healthy, in whom blast cells had disappeared by three months of age. In 6 patients, immunological studies revealed that more than 40% of blast cells were reactive to either platelet peroxidase (PPO) or antiplatelet glycoprotein (Gp) IIb/IIIa complex monoclonal antibodies. In the other two, those studies were not performed because the blast cells had disappeared within 1 week. Chromosomal analysis of blast cells showed all trisomy 21 and no marker chromosome. Colony assays of blood and marrow cells in methylcellulose were performed when diagnosis of TAM was made. CFU-C from blood was increased in three of the four cases. CFU-C from bone marrow was higher than normal in three of the five. These findings suggest that TAM represents a selective expansion of chromosome 21 trisomic blast cells which showed positive reaction to either PPO or Gp IIb/IIIa. The blast cells in TAM expressed megakaryocyte markers. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 104, 号 7, p. 593-597, 発行日 1990-07 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
