{"created":"2021-03-01T06:27:18.862692+00:00","id":22182,"links":{},"metadata":{"_buckets":{"deposit":"bab94415-10d5-4c24-a239-93a6c6c13d26"},"_deposit":{"id":"22182","owners":[],"pid":{"revision_id":0,"type":"depid","value":"22182"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00022182","sets":["453:456","471:537:538:1196"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Clinical Studies on 8 cases Transient Abnormal Myelopoiesis with Down Syndrome(20th Meeting of the Niigata Society of Hematologic Neoplasm The Ten-year Anniversary Symposium : Progress in Hematologic Neoplasm over the Ten Years)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"597","bibliographicPageStart":"593","bibliographicVolumeNumber":"104","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Transient abnormal myelopoiesis (TAM) with Down Syndrome is characterized by increased blast cells and resembles acute congenital leukemia. This disorder is unique in the point that the hematological abnormality is self-limiting. However, the association between TAM and the subsequent development of acute leukemia is not rully understood. We studied 8 patients of TAM with Down syndrome hospitalized during the recent 7 years. Clinical features of all patients were mostly compatible with the criteria proposed by Nagao, et al. Three had non immune hydorps fetalis (NIHF), two heart anomalies, one pulmonary leukostasis, two liver dysfunction, and two pancytopenia. Two died of NIHF after blast cells had disappeared and the other 6 are alive and healthy, in whom blast cells had disappeared by three months of age. In 6 patients, immunological studies revealed that more than 40% of blast cells were reactive to either platelet peroxidase (PPO) or antiplatelet glycoprotein (Gp) IIb/IIIa complex monoclonal antibodies. In the other two, those studies were not performed because the blast cells had disappeared within 1 week. Chromosomal analysis of blast cells showed all trisomy 21 and no marker chromosome. Colony assays of blood and marrow cells in methylcellulose were performed when diagnosis of TAM was made. CFU-C from blood was increased in three of the four cases. CFU-C from bone marrow was higher than normal in three of the five. These findings suggest that TAM represents a selective expansion of chromosome 21 trisomic blast cells which showed positive reaction to either PPO or Gp IIb/IIIa. The blast cells in TAM expressed megakaryocyte markers.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"134828","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ishizuka, Toshie"}]},{"nameIdentifiers":[{"nameIdentifier":"134829","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Oda, Yosihiko"}]},{"nameIdentifiers":[{"nameIdentifier":"134830","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takai, Kazue"}]},{"nameIdentifiers":[{"nameIdentifier":"134831","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sanada, Masayosi"}]},{"nameIdentifiers":[{"nameIdentifier":"134832","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Okazaki, Etuo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石塚, 利江"}],"nameIdentifiers":[{"nameIdentifier":"134823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小田, 良彦"}],"nameIdentifiers":[{"nameIdentifier":"134824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高井, 和江"}],"nameIdentifiers":[{"nameIdentifier":"134825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"真田, 雅好"}],"nameIdentifiers":[{"nameIdentifier":"134826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡崎, 悦夫"}],"nameIdentifiers":[{"nameIdentifier":"134827","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"104(7)_593-597.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"104(7)_593-597.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/22182/files/104(7)_593-597.pdf"},"version_id":"72a1309a-c6ac-4362-b68a-56c8e0ebeeac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Transient Abnormal Myelopoiesis (TAM)","subitem_subject_scheme":"Other"},{"subitem_subject":"Down症候群","subitem_subject_scheme":"Other"},{"subitem_subject":"PPO or Gp IIb/IIIa 陽性","subitem_subject_scheme":"Other"},{"subitem_subject":"染色体分析","subitem_subject_scheme":"Other"},{"subitem_subject":"コロニー形成能","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Down症候群の新生児にみられたtransient abnormal myelopoiesis（TAM）8例の臨床像（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Down症候群の新生児にみられたtransient abnormal myelopoiesis（TAM）8例の臨床像（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み）"},{"subitem_title":"Down症候群の新生児にみられたtransient abnormal myelopoiesis（TAM）8例の臨床像（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み）","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1196"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-16"},"publish_date":"2015-11-16","publish_status":"0","recid":"22182","relation_version_is_last":true,"title":["Down症候群の新生児にみられたtransient abnormal myelopoiesis（TAM）8例の臨床像（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み）"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:52:35.097622+00:00"}