{"_buckets": {"deposit": "0c468b10-b90e-4f81-b46e-dd13518f1265"}, "_deposit": {"id": "2161", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "2161"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00002161"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1997-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "950", "bibliographicPageStart": "941", "bibliographicVolumeNumber": "21", "bibliographic_titles": [{"bibliographic_title": "Leukemia Research"}, {"bibliographic_title": "Leukemia Research", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "A patient presented with chronic large granular lymphocytic leukemia after 13 years of mosquito allergy, recurrent fever, hepato-splenomegaly, liver dysfunction and chronic active EBV infection. Surface marker analysis of the leukemic cells showed the presence of CD2, CD8, CD16 and CD56, and absence of CD3, CD57 and HLA-DR. Cell cycle analysis revealed a minimal growth fraction compatible with chronic lymphocytic leukemia, and Southern blots of the cells showed monoclonal integration of EBV. After 5 months of treatment, the patient died from acute transformation of the leukemia and severe liver dysfunction. Cells harvested during chronic phase were analyzed for sensitivity to interleukin-2 (IL-2) and interferon-alpha (IFN\u03b1) in vitro by means of surface phenotyping and cell cycle assay. IL-2 induced remarkable growth of the cells, whereas IFN\u03b1 did not confer a growth advantage. Since IFN\u03b1 was expected to have no growth induction effect on the leukemia cells, it was administered to the patient to treat the chronic active EBV infection. There is always a risk of conferring a growth advantage upon cancer cells when growth factors or cytokines are administered in vivo as shown in this report.", "subitem_description_type": "Abstract"}]}, "item_5_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "7341", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "\u9ce5\u7fbd, \u5065"}]}]}, "item_5_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_5_rights_15": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Elsevier Ltd"}]}, "item_5_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00716755", "subitem_source_identifier_type": "NCID"}]}, "item_5_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "01452126", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Toba, Ken"}], "nameIdentifiers": [{"nameIdentifier": "7330", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koike, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "7331", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashimoto, Shigeo"}], "nameIdentifiers": [{"nameIdentifier": "7332", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Hoyu"}], "nameIdentifiers": [{"nameIdentifier": "7333", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uesugi, Yumiko"}], "nameIdentifiers": [{"nameIdentifier": "7334", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Toru"}], "nameIdentifiers": [{"nameIdentifier": "7335", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoki, Sadao"}], "nameIdentifiers": [{"nameIdentifier": "7336", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeo, Syougo"}], "nameIdentifiers": [{"nameIdentifier": "7337", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naito, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "7338", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aizawa, Yoshifusa"}], "nameIdentifiers": [{"nameIdentifier": "7339", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata, Akira"}], "nameIdentifiers": [{"nameIdentifier": "7340", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "24_0022.pdf", "filesize": [{"value": "7.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 7000000.0, "url": {"label": "24_0022.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/2161/files/24_0022.pdf"}, "version_id": "bac9305d-8dbf-4b19-bfe3-40f852e77794"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "granular lymphocytic leukemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mosquito allergy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ebstein-Barr virus", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hemophagocytic syndrome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "7AAD", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PY", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Characterization and sensitivity to interleukin-2 and interferoin-alpha of leukemic cells from a patient with large granular lymphocytic leukemia associated with chronic active Epstein-Barr virus infection", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Characterization and sensitivity to interleukin-2 and interferoin-alpha of leukemic cells from a patient with large granular lymphocytic leukemia associated with chronic active Epstein-Barr virus infection"}, {"subitem_title": "Characterization and sensitivity to interleukin-2 and interferoin-alpha of leukemic cells from a patient with large granular lymphocytic leukemia associated with chronic active Epstein-Barr virus infection", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["453/454", "482/483/484"], "permalink_uri": "http://hdl.handle.net/10191/1171", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-04-23"}, "publish_date": "2007-04-23", "publish_status": "0", "recid": "2161", "relation": {}, "relation_version_is_last": true, "title": ["Characterization and sensitivity to interleukin-2 and interferoin-alpha of leukemic cells from a patient with large granular lymphocytic leukemia associated with chronic active Epstein-Barr virus infection"], "weko_shared_id": null}