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  1. 0 資料タイプ別
  2. 01 学術雑誌論文
  1. 300 医歯学総合病院
  2. 10 学術雑誌論文
  3. 10 査読済論文

Characterization and sensitivity to interleukin-2 and interferoin-alpha of leukemic cells from a patient with large granular lymphocytic leukemia associated with chronic active Epstein-Barr virus infection

http://hdl.handle.net/10191/1171
http://hdl.handle.net/10191/1171
6a2974fd-2328-4353-9306-c9a6832f4460
名前 / ファイル ライセンス アクション
24_0022.pdf 24_0022.pdf (7.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-23
タイトル
言語 en
タイトル Characterization and sensitivity to interleukin-2 and interferoin-alpha of leukemic cells from a patient with large granular lymphocytic leukemia associated with chronic active Epstein-Barr virus infection
言語
言語 eng
キーワード
主題Scheme Other
主題 granular lymphocytic leukemia
キーワード
主題Scheme Other
主題 mosquito allergy
キーワード
主題Scheme Other
主題 Ebstein-Barr virus
キーワード
主題Scheme Other
主題 hemophagocytic syndrome
キーワード
主題Scheme Other
主題 7AAD
キーワード
主題Scheme Other
主題 PY
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Toba, Ken

× Toba, Ken

WEKO 7330

en Toba, Ken

Search repository
Koike, Tadashi

× Koike, Tadashi

WEKO 7331

en Koike, Tadashi

Search repository
Hashimoto, Shigeo

× Hashimoto, Shigeo

WEKO 7332

Hashimoto, Shigeo

Search repository
Takahashi, Hoyu

× Takahashi, Hoyu

WEKO 7333

en Takahashi, Hoyu

Search repository
Uesugi, Yumiko

× Uesugi, Yumiko

WEKO 7334

en Uesugi, Yumiko

Search repository
Ishikawa, Toru

× Ishikawa, Toru

WEKO 7335

en Ishikawa, Toru

Search repository
Aoki, Sadao

× Aoki, Sadao

WEKO 7336

en Aoki, Sadao

Search repository
Maeo, Syougo

× Maeo, Syougo

WEKO 7337

en Maeo, Syougo

Search repository
Naito, Makoto

× Naito, Makoto

WEKO 7338

en Naito, Makoto

Search repository
Aizawa, Yoshifusa

× Aizawa, Yoshifusa

WEKO 7339

en Aizawa, Yoshifusa

Search repository
Shibata, Akira

× Shibata, Akira

WEKO 7340

en Shibata, Akira

Search repository
著者別名
識別子 7341
識別子Scheme WEKO
姓名 鳥羽, 健
言語 ja
抄録
内容記述タイプ Abstract
内容記述 A patient presented with chronic large granular lymphocytic leukemia after 13 years of mosquito allergy, recurrent fever, hepato-splenomegaly, liver dysfunction and chronic active EBV infection. Surface marker analysis of the leukemic cells showed the presence of CD2, CD8, CD16 and CD56, and absence of CD3, CD57 and HLA-DR. Cell cycle analysis revealed a minimal growth fraction compatible with chronic lymphocytic leukemia, and Southern blots of the cells showed monoclonal integration of EBV. After 5 months of treatment, the patient died from acute transformation of the leukemia and severe liver dysfunction. Cells harvested during chronic phase were analyzed for sensitivity to interleukin-2 (IL-2) and interferon-alpha (IFNα) in vitro by means of surface phenotyping and cell cycle assay. IL-2 induced remarkable growth of the cells, whereas IFNα did not confer a growth advantage. Since IFNα was expected to have no growth induction effect on the leukemia cells, it was administered to the patient to treat the chronic active EBV infection. There is always a risk of conferring a growth advantage upon cancer cells when growth factors or cytokines are administered in vivo as shown in this report.
書誌情報 Leukemia Research
en : Leukemia Research

巻 21, 号 10, p. 941-950, 発行日 1997-10
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 0145-2126
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00716755
DOI
識別子タイプ DOI
関連識別子 http://doi.org/10.1016/s0145-2126(97)00057-x
権利
権利情報 Elsevier Ltd
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
著者版フラグ
値 author
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