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Characterization and sensitivity to interleukin-2 and interferoin-alpha of leukemic cells from a patient with large granular lymphocytic leukemia associated with chronic active Epstein-Barr virus infection
http://hdl.handle.net/10191/1171
http://hdl.handle.net/10191/11716a2974fd-2328-4353-9306-c9a6832f4460
名前 / ファイル | ライセンス | アクション |
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24_0022.pdf (7.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-04-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Characterization and sensitivity to interleukin-2 and interferoin-alpha of leukemic cells from a patient with large granular lymphocytic leukemia associated with chronic active Epstein-Barr virus infection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | granular lymphocytic leukemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mosquito allergy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ebstein-Barr virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hemophagocytic syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 7AAD | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PY | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Toba, Ken
× Toba, Ken× Koike, Tadashi× Hashimoto, Shigeo× Takahashi, Hoyu× Uesugi, Yumiko× Ishikawa, Toru× Aoki, Sadao× Maeo, Syougo× Naito, Makoto× Aizawa, Yoshifusa× Shibata, Akira |
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著者別名 | ||||||
識別子 | 7341 | |||||
識別子Scheme | WEKO | |||||
姓名 | 鳥羽, 健 | |||||
言語 | ja | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A patient presented with chronic large granular lymphocytic leukemia after 13 years of mosquito allergy, recurrent fever, hepato-splenomegaly, liver dysfunction and chronic active EBV infection. Surface marker analysis of the leukemic cells showed the presence of CD2, CD8, CD16 and CD56, and absence of CD3, CD57 and HLA-DR. Cell cycle analysis revealed a minimal growth fraction compatible with chronic lymphocytic leukemia, and Southern blots of the cells showed monoclonal integration of EBV. After 5 months of treatment, the patient died from acute transformation of the leukemia and severe liver dysfunction. Cells harvested during chronic phase were analyzed for sensitivity to interleukin-2 (IL-2) and interferon-alpha (IFNα) in vitro by means of surface phenotyping and cell cycle assay. IL-2 induced remarkable growth of the cells, whereas IFNα did not confer a growth advantage. Since IFNα was expected to have no growth induction effect on the leukemia cells, it was administered to the patient to treat the chronic active EBV infection. There is always a risk of conferring a growth advantage upon cancer cells when growth factors or cytokines are administered in vivo as shown in this report. | |||||
書誌情報 |
Leukemia Research en : Leukemia Research 巻 21, 号 10, p. 941-950, 発行日 1997-10 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0145-2126 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00716755 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://doi.org/10.1016/s0145-2126(97)00057-x | |||||
権利 | ||||||
権利情報 | Elsevier Ltd | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
著者版フラグ | ||||||
値 | author |