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  1. 0 資料タイプ別
  2. 01 学術雑誌論文
  1. 300 医歯学総合病院
  2. 10 学術雑誌論文
  3. 10 査読済論文

Simultaneous expression of CD13, CD22 and CD25 is related to the expression of FcεR1 in non-lymphoid leukemia

http://hdl.handle.net/10191/1178
http://hdl.handle.net/10191/1178
80e7d95c-6036-4d84-ad51-4b97ff07ff80
名前 / ファイル ライセンス アクション
24_0011.pdf 24_0011.pdf (1.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-23
タイトル
タイトル Simultaneous expression of CD13, CD22 and CD25 is related to the expression of FcεR1 in non-lymphoid leukemia
タイトル
言語 en
タイトル Simultaneous expression of CD13, CD22 and CD25 is related to the expression of FcεR1 in non-lymphoid leukemia
言語
言語 eng
キーワード
主題Scheme Other
主題 CD22
キーワード
主題Scheme Other
主題 Leu14
キーワード
主題Scheme Other
主題 FcεR1
キーワード
主題Scheme Other
主題 acute non-lymphocytic leukemia
キーワード
主題Scheme Other
主題 basophils
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sato, Naoko

× Sato, Naoko

WEKO 7233

Sato, Naoko

Search repository
Kishi, Kenji

× Kishi, Kenji

WEKO 7234

Kishi, Kenji

Search repository
Toba, Ken

× Toba, Ken

WEKO 7235

Toba, Ken

Search repository
Watanabe, Kenichi

× Watanabe, Kenichi

WEKO 7236

Watanabe, Kenichi

Search repository
Itoh, Hiromi

× Itoh, Hiromi

WEKO 7237

Itoh, Hiromi

Search repository
Narita, Miwako

× Narita, Miwako

WEKO 7238

Narita, Miwako

Search repository
Takahashi, Masuhiro

× Takahashi, Masuhiro

WEKO 7239

Takahashi, Masuhiro

Search repository
Aizawa, Yoshifusa

× Aizawa, Yoshifusa

WEKO 7240

Aizawa, Yoshifusa

Search repository
著者別名
識別子 7241
識別子Scheme WEKO
姓名 鳥羽, 健
抄録
内容記述タイプ Abstract
内容記述 Like CD19 or CD56, CD22 in non-lymphoid leukemia has been considered an aberrantly expressed antigen. CD22 had been believed to be restricted to B lymphoid, however, it was also found to be expressed in human basophils. Mature basophils are unique granulocytes expressing CD13, CD22 and CD25. To estimate whether the expression of CD22 in non-lymphoid leukemia is aberrant or related to basophilic character, we analyzed 108 patients with primary and secondary leukemia. Among non-lymphoid leukemias, surface CD22 expression was more frequently observed in peroxidase-negative AML and secondary leukemia, and was usually observed simultaneously with CD13 and CD25. Samples obtained from 17 cases were further analyzed, and all the FcεR1-positive cases were observed in peroxidase-negative AML and secondary non-lymphoid leukemia, and mostly expressed CD13, CD22 and CD25. Therefore, surface CD22 expression in non-lymphoid leukemia was thought to relate to basophilic phenotype in some cases. Like CD22, some of the so-called aberrantly expressed antigens may not actually be aberrant, but are expressed in a stage of differentiation and maturation of progenitors. Moreover, CD22 may be one of target molecules for treatment of CD22-positive, poorly prognostic leukemia.
書誌情報 Leukemia Research
en : Leukemia Research

巻 28, 号 7, p. 691-698, 発行日 2004-07
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 01452126
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00716755
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.leukres.2003.10.034
権利
権利情報 Elsevier Ltd
著者版フラグ
値 author
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