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Simultaneous expression of CD13, CD22 and CD25 is related to the expression of FcεR1 in non-lymphoid leukemia
http://hdl.handle.net/10191/1178
http://hdl.handle.net/10191/117880e7d95c-6036-4d84-ad51-4b97ff07ff80
名前 / ファイル | ライセンス | アクション |
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24_0011.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-04-23 | |||||
タイトル | ||||||
タイトル | Simultaneous expression of CD13, CD22 and CD25 is related to the expression of FcεR1 in non-lymphoid leukemia | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Simultaneous expression of CD13, CD22 and CD25 is related to the expression of FcεR1 in non-lymphoid leukemia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD22 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Leu14 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FcεR1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | acute non-lymphocytic leukemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | basophils | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Sato, Naoko
× Sato, Naoko× Kishi, Kenji× Toba, Ken× Watanabe, Kenichi× Itoh, Hiromi× Narita, Miwako× Takahashi, Masuhiro× Aizawa, Yoshifusa |
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著者別名 | ||||||
識別子 | 7241 | |||||
識別子Scheme | WEKO | |||||
姓名 | 鳥羽, 健 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Like CD19 or CD56, CD22 in non-lymphoid leukemia has been considered an aberrantly expressed antigen. CD22 had been believed to be restricted to B lymphoid, however, it was also found to be expressed in human basophils. Mature basophils are unique granulocytes expressing CD13, CD22 and CD25. To estimate whether the expression of CD22 in non-lymphoid leukemia is aberrant or related to basophilic character, we analyzed 108 patients with primary and secondary leukemia. Among non-lymphoid leukemias, surface CD22 expression was more frequently observed in peroxidase-negative AML and secondary leukemia, and was usually observed simultaneously with CD13 and CD25. Samples obtained from 17 cases were further analyzed, and all the FcεR1-positive cases were observed in peroxidase-negative AML and secondary non-lymphoid leukemia, and mostly expressed CD13, CD22 and CD25. Therefore, surface CD22 expression in non-lymphoid leukemia was thought to relate to basophilic phenotype in some cases. Like CD22, some of the so-called aberrantly expressed antigens may not actually be aberrant, but are expressed in a stage of differentiation and maturation of progenitors. Moreover, CD22 may be one of target molecules for treatment of CD22-positive, poorly prognostic leukemia. | |||||
書誌情報 |
Leukemia Research en : Leukemia Research 巻 28, 号 7, p. 691-698, 発行日 2004-07 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01452126 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00716755 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.leukres.2003.10.034 | |||||
権利 | ||||||
権利情報 | Elsevier Ltd | |||||
著者版フラグ | ||||||
値 | author |