{"created":"2021-03-01T06:05:50.856238+00:00","id":2152,"links":{},"metadata":{"_buckets":{"deposit":"0e8fea0c-3eaf-45f9-83f8-507b56619b94"},"_deposit":{"id":"2152","owners":[],"pid":{"revision_id":0,"type":"depid","value":"2152"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00002152","sets":["453:454","482:483:484"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"698","bibliographicPageStart":"691","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Leukemia Research"},{"bibliographic_title":"Leukemia Research","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Like CD19 or CD56, CD22 in non-lymphoid leukemia has been considered an aberrantly expressed antigen. CD22 had been believed to be restricted to B lymphoid, however, it was also found to be expressed in human basophils. Mature basophils are unique granulocytes expressing CD13, CD22 and CD25. To estimate whether the expression of CD22 in non-lymphoid leukemia is aberrant or related to basophilic character, we analyzed 108 patients with primary and secondary leukemia. Among non-lymphoid leukemias, surface CD22 expression was more frequently observed in peroxidase-negative AML and secondary leukemia, and was usually observed simultaneously with CD13 and CD25. Samples obtained from 17 cases were further analyzed, and all the FcεR1-positive cases were observed in peroxidase-negative AML and secondary non-lymphoid leukemia, and mostly expressed CD13, CD22 and CD25. Therefore, surface CD22 expression in non-lymphoid leukemia was thought to relate to basophilic phenotype in some cases. Like CD22, some of the so-called aberrantly expressed antigens may not actually be aberrant, but are expressed in a stage of differentiation and maturation of progenitors. Moreover, CD22 may be one of target molecules for treatment of CD22-positive, poorly prognostic leukemia.","subitem_description_type":"Abstract"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"7241","nameIdentifierScheme":"WEKO"}],"names":[{"name":"鳥羽, 健"}]}]},"item_5_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_5_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.leukres.2003.10.034","subitem_relation_type_select":"DOI"}}]},"item_5_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Elsevier Ltd"}]},"item_5_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00716755","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01452126","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Naoko"}],"nameIdentifiers":[{"nameIdentifier":"7233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kishi, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"7234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toba, Ken"}],"nameIdentifiers":[{"nameIdentifier":"7235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"7236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itoh, Hiromi"}],"nameIdentifiers":[{"nameIdentifier":"7237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Narita, Miwako"}],"nameIdentifiers":[{"nameIdentifier":"7238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Masuhiro"}],"nameIdentifiers":[{"nameIdentifier":"7239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aizawa, Yoshifusa"}],"nameIdentifiers":[{"nameIdentifier":"7240","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-29"}],"displaytype":"detail","filename":"24_0011.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24_0011.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/2152/files/24_0011.pdf"},"version_id":"d540b4cd-e0ca-480e-b4e5-13e3ec787285"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD22","subitem_subject_scheme":"Other"},{"subitem_subject":"Leu14","subitem_subject_scheme":"Other"},{"subitem_subject":"FcεR1","subitem_subject_scheme":"Other"},{"subitem_subject":"acute non-lymphocytic leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":"basophils","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Simultaneous expression of CD13, CD22 and CD25 is related to the expression of FcεR1 in non-lymphoid leukemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Simultaneous expression of CD13, CD22 and CD25 is related to the expression of FcεR1 in non-lymphoid leukemia"},{"subitem_title":"Simultaneous expression of CD13, CD22 and CD25 is related to the expression of FcεR1 in non-lymphoid leukemia","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["454","484"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-04-23"},"publish_date":"2007-04-23","publish_status":"0","recid":"2152","relation_version_is_last":true,"title":["Simultaneous expression of CD13, CD22 and CD25 is related to the expression of FcεR1 in non-lymphoid leukemia"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:34:59.548251+00:00"}